Comparing the Cognitive Effects of Repeated Intravenous Ketamine and Electroconvulsive Therapy in Patients With Treatment-Resistant Depression
This secondary analysis of a multisite randomized trial compared cognitive effects of repeated IV ketamine (six treatments) and electroconvulsive therapy (nine sessions) in 365 people with treatment-resistant depression. After the 3-week treatment course, the ECT group did worse than the ketamine group on four objective cognitive tests (P < .001).…