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6 papers
Social isolation and discrimination are linked with worse physical and mental health, more illness and higher death rates, and a lower quality of life. This review combines animal and human research and clinical studies. Animal studies show that social separation, especially early in life, activates the body's stress‑hormone system (the…
This randomized, double-blind trial tested whether six low-dose ketamine infusions over 12 days worked better than a single ketamine infusion for people with treatment-resistant depression. At 24 hours after the last infusion, there was no significant difference in clinician-rated depression scores between the group that received six ketamine infusions and…
In an open-label pilot study, 32 adults (ages 22–72; 53% female) with ongoing suicidal thoughts took low-dose oral ketamine for six weeks (starting at 0.5 mg/kg and titrated up to 3.0 mg/kg). Average scores on the Beck Scale for Suicide Ideation fell from a high level before treatment to below…
In a randomized trial, 98 adults with treatment-resistant depression had brain scans before and 24 hours after a single intravenous infusion of ketamine (0.5 mg/kg) or saline. The researchers measured mean diffusivity (DTI-MD), an MRI-based, indirect marker of microstructural brain change that tends to fall when new synapses or tissue…
This rat study tested whether stress during the peripuberty period (seven non-consecutive days between postnatal day 28 and 42) changed play fighting at adolescence and later brain markers. Rats exposed to peripubertal stress showed more play fighting at P45. The researchers found that animals with very high play fighting in…
This review combined 134 studies (159 experiments) that tried to tell apart people with autism spectrum disorder (ASD) from healthy controls using resting-state MRI. Across studies the pooled accuracy was moderate: about 76% sensitivity, 75.7% specificity, and an AUC of 0.823. However, the authors say there is a lot of…
