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Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Alternative medicine

3 papers

Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study

Vanina Popova, Ella Daly, Madhukar H. Trivedi, Kimberly Cooper, Rosanne Lane, Pilar Lim, et al.
American Journal of Psychiatry Summary & key facts 2019 839 citations

Researchers tested a nasal spray form of esketamine together with a newly started oral antidepressant in adults whose depression had not improved after trying at least two antidepressants. Over four weeks, people who got esketamine plus a new antidepressant had faster and larger drops in depression symptoms than those who…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Treatment of Major Depression Tryptophan and brain disorders Ketamine

Antidepressants versus placebo for generalised anxiety disorder (GAD)

Katarina Kopcalic, Justin Arcaro, Antonio Pinto, Shehzad Ali, Corrado Barbui, Chiara Curatoli, et al.
Cochrane Database of Systematic Reviews Summary & key facts 2025 11 citations

This Cochrane review pooled 37 randomized trials with 12,226 adults who had moderate to severe generalized anxiety disorder (GAD). It found antidepressants were more effective than placebo at improving anxiety symptoms, with high confidence in the main results. Overall dropout rates were similar between antidepressants and placebo, but fewer people…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Perfectionism, Procrastination, Anxiety Studies

The effect of slow breathing in regulating anxiety

Qian Luo, Xianrui Li, Jia Zhao, Jiang Qiu, Dongtao Wei
Scientific Reports Summary & key facts 2025 11 citations

This study tested how slow versus fast breathing affects anxiety and brain activity. Twenty-seven people did breathing and threat-uncertainty tasks while their brain activity was measured with EEG. Slow breathing reduced anxiety and led to different EEG patterns than fast breathing. In particular, slow breathing raised EEG power across several…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Heart Rate Variability and Autonomic Control Psychosomatic Disorders and Their Treatments
Summaries and links are for general information and education only. They are not a substitute for reading the original publication or for professional medical, legal, or other advice. Always refer to the linked source for the full study.