Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

7 papers

Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial

Roland R. Griffiths, Matthew W. Johnson, Michael A. Carducci, Annie Umbricht, William A. Richards, Brian D. Richards, et al.
Journal of Psychopharmacology Summary & key facts 2016 2,068 citations

This randomized, double‑blind, cross‑over trial gave 51 patients with life‑threatening cancer two sessions of psilocybin (one very low dose and one high dose) spaced five weeks apart. The high dose (22–30 mg/70 kg) produced large drops in clinician‑ and self‑rated depression and anxiety, and increased quality of life, meaning, and…

Cannabis and Cannabinoid Research Complementary and Alternative Medicine Studies Psychedelics and Drug Studies

Ethics and ego dissolution: the case of psilocybin

William Smith, Dominic Sisti
Journal of Medical Ethics Summary & key facts 2020 130 citations

Recent, early-phase trials suggest psychedelics—especially psilocybin—may help treat several mental and substance use disorders. The psychedelic experience can include loss of self-importance, feelings of unity or connection, ineffable insights, and encounters with ‘deep’ reality or God, and it can change a person’s personality and worldview. The authors argue these unusual…

Chemical synthesis and alkaloids Complementary and Alternative Medicine Studies Psychedelics and Drug Studies

The Effect of Aromatherapy on Anxiety in Patients

Farzaneh Barati, Ahmad Nasiri, Negarin Akbari, Gholamreza Sharifzadeh
Nephro-Urology Monthly Summary & key facts 2016 75 citations

This randomized trial tested rose water inhalation in 46 hemodialysis patients. One group inhaled rose water for 4 weeks and the other group had no intervention. After 4 weeks the treated group had lower average state and trait anxiety scores, and the reductions were statistically significant (P < 0.001). The…

Complementary and Alternative Medicine Studies Fibromyalgia and Chronic Fatigue Syndrome Research Olfactory and Sensory Function Studies

Ayurveda: a historical perspective and principles of the traditional healthcare system in India

L.C. Mishra, Balwant Singh, Simon Dagenais
PubMed 2001 75 citations

This paper gives a historical overview of Ayurveda, the traditional Indian system of healthcare. It says Ayurveda has been used for more than 5,000 years and was well established around 2500–600 BC. The article describes core ideas of the system (doshas, dhatus, and gunas), names classic texts, and says treatments…

Complementary and Alternative Medicine Studies

Harnessing the Four Elements for Mental Health

Jerome Sarris, Michael de Manincor, Fiona Hargraves, Jack Tsonis
PubMed Summary & key facts 2019 21 citations

This 2019 scoping review explores how the four classical elements—Fire, Water, Earth, and Air—can map onto modern, changeable exposures and therapies that might affect mental health. The authors summarize emerging evidence from both population studies and intervention trials for things like UV or heat therapy (Fire), sauna and hydrotherapy (Water),…

Complementary and Alternative Medicine Studies Mindfulness and Compassion Interventions Urban Green Space and Health

Is microdosing a placebo? A rapid review of low-dose LSD and psilocybin research

Vince Polito, Paul Liknaitzky
Journal of Psychopharmacology Summary & key facts 2024 14 citations

Researchers reviewed 19 placebo-controlled studies that tested low doses of LSD or psilocybin (this is called microdosing). The studies found measurable changes in brain biology, body responses, how people felt, and how they thought, compared with placebo. But the studies are few and small, often tested only tiny doses in…

Chemical synthesis and alkaloids Complementary and Alternative Medicine Studies Psychedelics and Drug Studies LSD Psilocybin

Comforting delusions? How to evaluate the plausibility of mystical-type insights in psychedelic experiences

Jussi Jylkkä
Philosophical Psychology Summary & key facts 2024 8 citations

The paper says that psychedelics can produce mystical-type beliefs, like the idea that reality is a loving consciousness. The author argues we should not call these beliefs delusional just because they clash with naturalism (the view that only natural stuff exists). Instead, the paper recommends “metaphysical agnosticism” — holding off…

Complementary and Alternative Medicine Studies Olfactory and Sensory Function Studies Psychedelics and Drug Studies
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