Frontier mental health research: psychedelics & drug studies

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11 papers

Anxiety

Based on 52 papers

Research points to two clear groups of treatments for anxiety. First, ordinary approaches like exercise — especially walking and other regular physical activity — have strong, high-quality evidence showing medium-sized reductions in anxiety symptoms. These are proven in many randomized trials and reviews. Second, newer substance-assisted therapies (often called psychedelic‑assisted therapy) are promising. Small clinical trials and reviews show reductions in anxiety and related problems after carefully supervised doses of drugs such as psilocybin, MDMA, ketamine, and ayahuasca. However, these drug approaches are mostly early-stage or done in special research settings and need more, larger trials before they can become routine care. People thinking about or treating anxiety should know that drug‑assisted therapies are almost always given together with serious psychological support. How the drug is given, the preparation before it, and follow-up therapy matter a lot. There are also safety and equity issues to watch: some psychedelics can have rare lasting side effects, many studies are small, and people of color have been underrepresented in trials. For now, exercise has the clearest and broadest evidence. Other treatments are promising but still need more testing and careful medical oversight.

Key findings

  • Many high-quality reviews find regular physical activity reduces anxiety by a medium amount across many trials. 8792
  • Walking specifically lowers anxiety symptoms compared with doing nothing, based on 26 randomized trials pooled together. 8785
  • Clinical trials and reviews report that psychedelic-assisted therapies (drugs given with therapy) reduced anxiety symptoms in people diagnosed with anxiety disorders. 15068 15063 15056
  • For post‑traumatic stress disorder (a trauma-related anxiety condition), MDMA given with psychotherapy produced large benefits in several controlled trials. 15063
  • Psychedelic drugs appear to change the brain in ways that could help anxiety and mood problems. Lab and imaging studies report increased brain plasticity (the brain’s ability to form new connections) and changes in inflammation and brain networks after substances like psilocybin, DMT, and other psychedelics. 15132 15050 15091 15135
  • Ketamine produces fast antidepressant effects and has been tested as an alternative to electroconvulsive therapy; it has also been studied for anxiety-related conditions in some trials. 10149 10160 15068
  • Most studies of psilocybin and other classic psychedelics are small and done with close medical and psychological support, so experts say larger, well‑controlled trials are still needed before routine use. 15056 15078
  • How people are prepared and supported matters a lot: many guides and reviews agree that screening, setting expectations, building trust, and follow‑up therapy are core parts of substance‑assisted psychotherapy. 15065 15092 15063
  • People of color were underrepresented in many psychedelic-assisted psychotherapy studies, which limits how well the results apply to different ethnic groups. 15095
  • There are risks to be aware of: rare but long-lasting perceptual problems (called HPPD) and other psychological or physical side effects have been reported after hallucinogen use, so safety monitoring is important. 15048 15087

Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic

COVID-19 Mental Disorders Collaborators
PubMed Central (PMC) Summary & key facts 2021 5,135 citations

This study reviewed surveys and used global models to measure how the COVID-19 pandemic changed rates of major depressive disorder and anxiety disorders in 2020. It found that places with higher COVID-19 infection rates and bigger drops in movement had larger increases in these disorders. The authors estimate about 53.2…

COVID-19 and Mental Health Health disparities and outcomes Long-Term Effects of COVID-19

Mindfulness-Based Stress Reduction for Stress Management in Healthy People: A Review and Meta-Analysis

Alberto Chiesa, Alessandro Serretti

MBSR is able to reduce stress levels in healthy people. However, important limitations of the included studies as well as the paucity of evidence about possible specific effects of MBSR in comparison to other nonspecific treatments underline the necessity of further research.

COVID-19 and Mental Health Mindfulness and Compassion Interventions Resilience and Mental Health

Mindfulness-Based Interventions for Anxiety and Depression

Stefan G Hofmann, Angelina F Gómez
PubMed Central (PMC) Summary & key facts 2017 706 citations

Mindfulness-based interventions (MBIs), especially Mindfulness-Based Stress Reduction (MBSR) and Mindfulness-Based Cognitive Therapy (MBCT), teach people to pay nonjudgmental attention to the present moment. Reviews and randomized trials show MBIs can reduce anxiety and depression symptom severity across many groups, often doing better than non-evidence treatments or active controls and performing…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Mindfulness and Compassion Interventions

Social support and mental health: the mediating role of perceived stress

Acoba, Evelyn F.
www.frontiersin.org Summary & key facts 2024 281 citations

This study surveyed 426 Filipino adults online during the peak of the COVID-19 pandemic to see if perceived stress helps explain links between social support and mental health. Using standard questionnaires, the researchers found that lower perceived stress was linked to more positive feelings and less anxiety and depression when…

COVID-19 and Mental Health Health disparities and outcomes Psychological Well-being and Life Satisfaction

Brief structured respiration practices enhance mood and reduce physiological arousal

Melis Yilmaz Balban, Eric Neri, Manuela M. Kogon, Lara Weed, Bita Nouriani, Booil Jo, et al.
Summary & key facts 226 citations

In a remote, randomized trial (NCT05304000), people did one of three five-minute daily breathing exercises or five minutes of mindfulness meditation each day for one month. The researchers measured mood, anxiety, and physiological arousal (breathing rate, heart rate, and heart rate variability). Breathwork—especially exhale-focused cyclic sighing—produced bigger mood gains and…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Mindfulness and Compassion Interventions

The Influence of the COVID-19 Pandemic on Social Anxiety: A Systematic Review

Reuben Kindred, Glen Bates

This systematic review looked at 33 studies about social anxiety during the COVID-19 pandemic. The studies suggest social anxiety increased in the general population. Women and people with low incomes appeared more likely to report higher social anxiety. Other links to higher social anxiety included poor coping, weaker social support,…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Perfectionism, Procrastination, Anxiety Studies

Physician Anxiety and Burnout: Symptom Correlates and a Prospective Pilot Study of App-Delivered Mindfulness Training

Alexandra Roy, Susan Druker, Elizabeth A. Hoge, Judson A. Brewer
JMIR mhealth and uhealth Summary & key facts 2020 56 citations

This small, nonrandomized pilot study gave a 30-day app-based mindfulness program (about 10 minutes per day) to 34 physicians who reported anxiety. Average anxiety scores fell by 48% after 1 month and by 57% after 3 months. Measures of burnout (cynicism and emotional exhaustion) were correlated with anxiety and also…

COVID-19 and Mental Health Healthcare professionals’ stress and burnout Perfectionism, Procrastination, Anxiety Studies

Rising global burden of anxiety disorders among adolescents and young adults: trends, risk factors, and the impact of socioeconomic disparities and COVID-19 from 1990 to 2021

Fengsai Bie, Xiao-ling YAN, Jie Xing, Leilei Wang, Yang Xu, Guan Wang, et al.
Frontiers in Psychiatry Summary & key facts 2024 41 citations

This study analyzed Global Burden of Disease (GBD) 2021 data from 204 countries to track anxiety disorders in 10–24 year olds from 1990 to 2021. It found a 52% rise in incidence over those 31 years, a sharp increase after 2019, higher rates in females, and rising disability (DALYs) especially…

Bullying, Victimization, and Aggression Child and Adolescent Psychosocial and Emotional Development COVID-19 and Mental Health

A systematic review of brief respiratory, embodiment, cognitive, and mindfulness interventions to reduce state anxiety

Chin, Phoebe, Gorman, Faye, Beck, Fraser, et al.
www.frontiersin.org Summary & key facts 2024 8 citations

This review looked at short, single-session psychological techniques aimed at lowering state anxiety. The authors found 12 randomized trials and reported that cognitive and embodiment exercises tended to reduce anxiety, while breathing-only exercises gave mixed results. Combined approaches like mindfulness showed moderate benefits when they used passive attention, but results…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Mindfulness and Compassion Interventions

Acceptance and Commitment Therapy and Psychological Well-Being: A Narrative Review

Anusuya S P, Gayatridevi S
PubMed Central (PMC) Summary & key facts 2025 7 citations

Acceptance and commitment therapy (ACT) is a therapy that teaches people to accept hard thoughts and feelings and to act in line with their values. This review reports that many studies, including randomized controlled trials and meta-analyses, find ACT can improve parts of psychological well-being such as emotional regulation, life…

COVID-19 and Mental Health Mindfulness and Compassion Interventions Psychological Well-being and Life Satisfaction
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