Frontier mental health research: psychedelics & drug studies

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14 papers

Anxiety

Based on 52 papers

Research points to two clear groups of treatments for anxiety. First, ordinary approaches like exercise — especially walking and other regular physical activity — have strong, high-quality evidence showing medium-sized reductions in anxiety symptoms. These are proven in many randomized trials and reviews. Second, newer substance-assisted therapies (often called psychedelic‑assisted therapy) are promising. Small clinical trials and reviews show reductions in anxiety and related problems after carefully supervised doses of drugs such as psilocybin, MDMA, ketamine, and ayahuasca. However, these drug approaches are mostly early-stage or done in special research settings and need more, larger trials before they can become routine care. People thinking about or treating anxiety should know that drug‑assisted therapies are almost always given together with serious psychological support. How the drug is given, the preparation before it, and follow-up therapy matter a lot. There are also safety and equity issues to watch: some psychedelics can have rare lasting side effects, many studies are small, and people of color have been underrepresented in trials. For now, exercise has the clearest and broadest evidence. Other treatments are promising but still need more testing and careful medical oversight.

Key findings

  • Many high-quality reviews find regular physical activity reduces anxiety by a medium amount across many trials. 8792
  • Walking specifically lowers anxiety symptoms compared with doing nothing, based on 26 randomized trials pooled together. 8785
  • Clinical trials and reviews report that psychedelic-assisted therapies (drugs given with therapy) reduced anxiety symptoms in people diagnosed with anxiety disorders. 15068 15063 15056
  • For post‑traumatic stress disorder (a trauma-related anxiety condition), MDMA given with psychotherapy produced large benefits in several controlled trials. 15063
  • Psychedelic drugs appear to change the brain in ways that could help anxiety and mood problems. Lab and imaging studies report increased brain plasticity (the brain’s ability to form new connections) and changes in inflammation and brain networks after substances like psilocybin, DMT, and other psychedelics. 15132 15050 15091 15135
  • Ketamine produces fast antidepressant effects and has been tested as an alternative to electroconvulsive therapy; it has also been studied for anxiety-related conditions in some trials. 10149 10160 15068
  • Most studies of psilocybin and other classic psychedelics are small and done with close medical and psychological support, so experts say larger, well‑controlled trials are still needed before routine use. 15056 15078
  • How people are prepared and supported matters a lot: many guides and reviews agree that screening, setting expectations, building trust, and follow‑up therapy are core parts of substance‑assisted psychotherapy. 15065 15092 15063
  • People of color were underrepresented in many psychedelic-assisted psychotherapy studies, which limits how well the results apply to different ethnic groups. 15095
  • There are risks to be aware of: rare but long-lasting perceptual problems (called HPPD) and other psychological or physical side effects have been reported after hallucinogen use, so safety monitoring is important. 15048 15087

Mindfulness-Based Stress Reduction for Stress Management in Healthy People: A Review and Meta-Analysis

Alberto Chiesa, Alessandro Serretti

MBSR is able to reduce stress levels in healthy people. However, important limitations of the included studies as well as the paucity of evidence about possible specific effects of MBSR in comparison to other nonspecific treatments underline the necessity of further research.

COVID-19 and Mental Health Mindfulness and Compassion Interventions Resilience and Mental Health

Mindfulness-Based Interventions for Anxiety and Depression

Stefan G Hofmann, Angelina F Gómez
PubMed Central (PMC) Summary & key facts 2017 706 citations

Mindfulness-based interventions (MBIs), especially Mindfulness-Based Stress Reduction (MBSR) and Mindfulness-Based Cognitive Therapy (MBCT), teach people to pay nonjudgmental attention to the present moment. Reviews and randomized trials show MBIs can reduce anxiety and depression symptom severity across many groups, often doing better than non-evidence treatments or active controls and performing…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Mindfulness and Compassion Interventions

A Randomized Controlled Effectiveness Trial of Acceptance and Commitment Therapy and Cognitive Therapy for Anxiety and Depression

Evan M. Forman, James D. Herbert, Ethan Moitra, Peter D. Yeomans, Pamela A. Geller
Behavior Modification Summary & key facts 2007 682 citations

The source explains what Acceptance and Commitment Therapy (ACT) is and reports research comparing ACT with cognitive therapy (CT). In a randomized trial of 101 outpatients with moderate to severe anxiety or depression, people assigned to ACT or to CT showed large, similar improvements in depression, anxiety, daily functioning, quality…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Complementary and Alternative Medicine Studies Mindfulness and Compassion Interventions

Brief structured respiration practices enhance mood and reduce physiological arousal

Melis Yilmaz Balban, Eric Neri, Manuela M. Kogon, Lara Weed, Bita Nouriani, Booil Jo, et al.
Summary & key facts 226 citations

In a remote, randomized trial (NCT05304000), people did one of three five-minute daily breathing exercises or five minutes of mindfulness meditation each day for one month. The researchers measured mood, anxiety, and physiological arousal (breathing rate, heart rate, and heart rate variability). Breathwork—especially exhale-focused cyclic sighing—produced bigger mood gains and…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Mindfulness and Compassion Interventions

Breathing‐Based Meditation Decreases Posttraumatic Stress Disorder Symptoms in U.S. Military Veterans: A Randomized Controlled Longitudinal Study

Emma Seppälä, Jack B. Nitschke, Dana Tudorascu, Andrea S Hayes, Michael R. Goldstein, Dong T. H. Nguyen, et al.
Journal of Traumatic Stress Summary & key facts 2014 177 citations

This randomized study tested a breathing-based meditation (Sudarshan Kriya yoga) in 21 male U.S. veterans of the Iraq or Afghanistan wars. Participants were randomly assigned to the meditation group (n = 11) or a waitlist control (n = 10). The meditation group showed reductions in self-reported PTSD symptoms, anxiety, and…

Mindfulness and Compassion Interventions Posttraumatic Stress Disorder Research Stress Responses and Cortisol

Mindful awareness in body-oriented therapy as an adjunct to women’s substance use disorder treatment: a pilot feasibility study

Cynthia Price, Elizabeth A. Wells, Dennis M. Donovan, Tessa Rue
PubMed Summary & key facts 2012 90 citations

This small randomized pilot study tested a therapy called Mindful Awareness in Body-Oriented Therapy (MABT) as an extra treatment for women in substance use disorder (SUD) care. Forty-six women were enrolled and those in the MABT group received eight weekly one-on-one sessions in addition to usual care. At the main…

Eating Disorders and Behaviors Mindfulness and Compassion Interventions Psychosomatic Disorders and Their Treatments

Differential Experimental Effects of a Short Bout of Walking, Meditation, or Combination of Walking and Meditation on State Anxiety Among Young Adults

Meghan K. Edwards, Simon Rosenbaum, Paul D. Loprinzi

This randomized trial tested whether a single short bout of walking, meditation, or a combination changed short-term anxiety in young adults. One hundred ten university students (mean age 21.4 years) were randomly assigned to 10 minutes of walking, 10 minutes of meditation, walking then meditation, meditation then walking, or sitting.…

Mindfulness and Compassion Interventions Sleep and related disorders Urban Green Space and Health

A multisensory mindfulness experience: exploring the promotion of sensory awareness as a mindfulness practice

Finck, Carolyn, Avila, Alba, Jiménez-Leal, William, et al.
www.frontiersin.org Summary & key facts 2023 10 citations

This was a small, preliminary study that tested two short mindfulness setups: (a) an audio-only guided practice and (b) a multisensory experience (smell, sound, light) followed by a biofeedback display of the user’s heartbeat. Sixty-eight people took part. Heart-rate variability (HRV) data showed an increase in parasympathetic activity after the…

Mindfulness and Compassion Interventions Olfactory and Sensory Function Studies Urban Green Space and Health

A systematic review of brief respiratory, embodiment, cognitive, and mindfulness interventions to reduce state anxiety

Chin, Phoebe, Gorman, Faye, Beck, Fraser, et al.
www.frontiersin.org Summary & key facts 2024 8 citations

This review looked at short, single-session psychological techniques aimed at lowering state anxiety. The authors found 12 randomized trials and reported that cognitive and embodiment exercises tended to reduce anxiety, while breathing-only exercises gave mixed results. Combined approaches like mindfulness showed moderate benefits when they used passive attention, but results…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Mindfulness and Compassion Interventions

Acceptance and Commitment Therapy and Psychological Well-Being: A Narrative Review

Anusuya S P, Gayatridevi S
PubMed Central (PMC) Summary & key facts 2025 7 citations

Acceptance and commitment therapy (ACT) is a therapy that teaches people to accept hard thoughts and feelings and to act in line with their values. This review reports that many studies, including randomized controlled trials and meta-analyses, find ACT can improve parts of psychological well-being such as emotional regulation, life…

COVID-19 and Mental Health Mindfulness and Compassion Interventions Psychological Well-being and Life Satisfaction

Residential Meditation Retreats: A Promise of Sustainable Well-Being?

Selvaraj Giridharan
Cureus Summary & key facts 2024 2 citations

Residential meditation retreats are live-in programs of intensive meditation, mindfulness, and intentional rest. Reviews and studies report reduced stress, anxiety, and depression and some physical changes (for example, lower inflammatory markers and a 3% average weight drop in one study). Some benefits lasted weeks after the retreat, but the evidence…

Dietary Effects on Health Mindfulness and Compassion Interventions Physical Activity and Health
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