Frontier mental health research: psychedelics & drug studies

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14 papers

The World Health Organization Adult ADHD Self-Report Scale (ASRS): a short screening scale for use in the general population

Ronald C. Kessler, Lenard A. Adler, Minnie Ames, Olga Demler, Stephen V. Faraone, Eva Hiripi, et al.
PubMed Summary & key facts 2005 3,245 citations

The WHO Adult ADHD Self-Report Scale (ASRS) has 18 questions about recent ADHD symptoms, and a shorter six-question screener was tested against blind clinical diagnoses in 154 people from the US National Comorbidity Survey Replication. Each ASRS item was linked to the clinical rating, but agreement varied a lot across…

Attention Deficit Hyperactivity Disorder Functional Brain Connectivity Studies Neural and Behavioral Psychology Studies

The Prevalence and Correlates of Adult ADHD in the United States: Results From the National Comorbidity Survey Replication

Ronald C. Kessler
American Journal of Psychiatry Summary & key facts 2006 2,956 citations

This U.S. study used a nationally representative household survey of 3,199 adults aged 18–44, plus clinical follow-up interviews, to measure adult ADHD. Researchers estimated that 4.4% of adults had current ADHD. Adult ADHD was more common in men, people who were previously married, those who were unemployed, and non-Hispanic white…

Attention Deficit Hyperactivity Disorder Child and Adolescent Psychosocial and Emotional Development Functional Brain Connectivity Studies

Adult ADHD and comorbid disorders: clinical implications of a dimensional approach

Martin A. Katzman, Timothy S. Bilkey, Pratap Chokka, Angelo Fallu, Larry J. Klassen
BMC Psychiatry Summary & key facts 2017 648 citations

This review says adult ADHD affects about 2.5% of adults and often occurs with other mental health problems. Adults with ADHD commonly have trouble with attention, memory, planning, self-control, and emotions. The condition is often missed or undertreated, is linked with big personal and social problems, and the evidence on…

Attention Deficit Hyperactivity Disorder Functional Brain Connectivity Studies Neural and Behavioral Psychology Studies

Gender effects on Attention-Deficit/Hyperactivity disorder in adults, revisited

Joseph Biederman, Stephen V. Faraone, Michael C. Monuteaux, Marie Bober, Elizabeth Cadogen
Biological Psychiatry Summary & key facts 2004 380 citations

This study reexamined gender differences in adult ADHD by comparing 219 adults with ADHD to 215 control subjects matched for age and gender. The researchers found no evidence that gender changed how ADHD related to other psychiatric disorders. Adults with ADHD showed cognitive deficits and higher rates of major depression,…

Attention Deficit Hyperactivity Disorder Child and Adolescent Psychosocial and Emotional Development Functional Brain Connectivity Studies

Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation

Katya Rubia
Frontiers in Human Neuroscience Summary & key facts 2018 354 citations

Brain imaging studies (fMRI) show that ADHD is linked to problems in many brain networks that control attention, timing, working memory, motivation, and emotion. There is also evidence that a brain system normally quiet during tasks (the default mode network) does not switch off properly in people with ADHD. Some…

Attention Deficit Hyperactivity Disorder Functional Brain Connectivity Studies Transcranial Magnetic Stimulation Studies

Underdiagnosis of Attention-Deficit/Hyperactivity Disorder in Adult Patients

Ylva Ginsberg, Javier Quintero, Ernie Anand, Marta Casillas, Himanshu P. Upadhyaya

This review found that ADHD often continues from childhood into adulthood but is commonly missed and untreated in grown-ups. It estimates adult ADHD affects about 2.5%–5% of the general population and says fewer than 20% of adults with ADHD are diagnosed or treated. Adults with ADHD often have other mental…

Attention Deficit Hyperactivity Disorder Autism Spectrum Disorder Research Functional Brain Connectivity Studies

ADHD and the Prefrontal Cortex

Amy F.T. Arnsten
The Journal of Pediatrics Summary & key facts 2009 198 citations

Research links ADHD — which shows up as inattention, impulsivity, and too much activity — to weaker structure and function in the brain’s prefrontal cortex (PFC), especially on the right side. The PFC helps control top-down attention, stop inappropriate actions, and regulate emotion, and it needs the right balance of…

Attention Deficit Hyperactivity Disorder Functional Brain Connectivity Studies Neural and Behavioral Psychology Studies

ADHD and depression: investigating a causal explanation

Lucy Riglin, Beate Leppert, Christina Dardani, Ajay K. Thapar, Ajay K. Thapar, Frances Rice, et al.
Psychological Medicine Summary & key facts 2020 138 citations

This study used a long-term UK birth cohort (N = 8,310) and genetic analyses to test whether childhood ADHD is linked to depression later in life. Children with ADHD at age 7 had higher odds of recurrent depression in young adulthood (OR 1.35, 95% CI 1.05–1.73). Genetic analyses (Mendelian randomization)…

Attention Deficit Hyperactivity Disorder Functional Brain Connectivity Studies Health, Environment, Cognitive Aging

Attention-deficit hyperactivity disorder (ADHD) stimulant medications as cognitive enhancers

Claire Advokat, Mindy Scheithauer
Frontiers in Neuroscience Summary & key facts 2013 62 citations

This review looked at studies of ADHD stimulant drugs (like methylphenidate and amphetamine). The drugs clearly reduce core ADHD symptoms for many people, but they do not reliably make ADHD students do better in school or on many cognitive tests in real-world settings. The drugs helped one type of memory…

Attention Deficit Hyperactivity Disorder Functional Brain Connectivity Studies Neuroethics, Human Enhancement, Biomedical Innovations

Attention-Deficit/Hyperactivity Disorder Predominantly Inattentive Subtype/Presentation: Research Progress and Translational Studies

Ike dela Peña, Michael C. Pan, Chau Giang Thai, Tamara Alisso
Brain Sciences Summary & key facts 2020 43 citations

Research on the predominantly inattentive attention-deficit/hyperactivity disorder (ADHD-PI) subtype/presentation is important given its high prevalence, but paradoxically it is under-recognized and undertreated. The temporal stability of the inattention symptom could impact the high worldwide prevalence of ADHD-PI. Some evidence suggests differences in the nature of attentional deficit in ADHD-PI vs.…

Attention Deficit Hyperactivity Disorder Functional Brain Connectivity Studies Neural and Behavioral Psychology Studies

Mindfulness-Based Cognitive Therapy and the Adult ADHD Brain: A Neuropsychotherapeutic Perspective

Katharina Bachmann, Alexandra P. Lam, Alexandra Philipsen
Frontiers in Psychiatry Summary & key facts 2016 32 citations

This paper reviews evidence and ideas about using mindfulness-based cognitive therapy (MBCT) as a non-drug way to help adults with ADHD. It explains that ADHD is linked to abnormal activity in specific brain circuits and that the usual drug treatment, methylphenidate, helps some people but has limits. The authors argue…

Attention Deficit Hyperactivity Disorder Functional Brain Connectivity Studies Mindfulness and Compassion Interventions

‘Shine bright like a diamond!’: is research on high‐functioning ADHD at last entering the mainstream?

Klaus‐Peter Lesch

This ADDA article explains “high‑functioning ADHD” as when a person has ADHD symptoms but still manages daily life, often by using special strategies. It says high‑functioning ADHD is not an official diagnosis, can be hard to spot because coping methods hide symptoms, and that these workarounds can be tiring and…

Attention Deficit Hyperactivity Disorder Autism Spectrum Disorder Research Functional Brain Connectivity Studies
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