Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

10 papers

Causes of Persistent Dizziness

Kurt Kroenke, Christine Lucas, Michael L. Rosenberg, Barbara Scherokman, Jerome E. Herbers, Paul A. Wehrle, et al.
Annals of Internal Medicine Summary & key facts 1992 262 citations

Researchers followed 100 outpatients (mean age 62) who kept having dizziness. They found that problems of the vestibular system (inner ear and balance) and psychiatric disorders were the most common causes. About half the patients had more than one factor making dizziness worse, and life‑threatening causes were rare.

Neuroscience of respiration and sleep Obstructive Sleep Apnea Research Vestibular and auditory disorders

Brief structured respiration practices enhance mood and reduce physiological arousal

Melis Yilmaz Balban, Eric Neri, Manuela M. Kogon, Lara Weed, Bita Nouriani, Booil Jo, et al.
Summary & key facts 226 citations

In a remote, randomized trial (NCT05304000), people did one of three five-minute daily breathing exercises or five minutes of mindfulness meditation each day for one month. The researchers measured mood, anxiety, and physiological arousal (breathing rate, heart rate, and heart rate variability). Breathwork—especially exhale-focused cyclic sighing—produced bigger mood gains and…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Mindfulness and Compassion Interventions

Effects of voluntary slow breathing on heart rate and heart rate variability: A systematic review and a meta-analysis

Sylvain Laborde, Mark S. Allen, Uirassu Borges, Fabrice Dosseville, Thomas J. Hosang, Maša Iskra, et al.
PubMed Summary & key facts 2022 205 citations

This 2022 systematic review and meta-analysis pooled data from 223 studies to see if voluntary slow breathing (VSB) changes heart rate variability that reflects parasympathetic (vagal) control of the heart. The authors found that VSB increased vagally-mediated heart rate variability during breathing sessions, right after a single session, and after…

Cardiac Health and Mental Health Cardiovascular and exercise physiology Heart Rate Variability and Autonomic Control

Moderate Pressure Massage Elicits a Parasympathetic Nervous System Response

Miguel Diego, Tiffany Field

In a randomized trial of 20 healthy adults, researchers recorded EKGs during a 3-minute baseline, a 15-minute massage, and a 3-minute postmassage period. Moderate pressure massage raised the high-frequency (HF) heart-rate variability measure and lowered the LF/HF ratio, which the authors say indicates increased parasympathetic (vagal) activity peaking in the…

Acupuncture Treatment Research Studies Heart Rate Variability and Autonomic Control Psychosomatic Disorders and Their Treatments

Benefits from one session of deep and slow breathing on vagal tone and anxiety in young and older adults

Valentin Magnon, Fréderic Dutheil, Guillaume T. Vallet
PubMed Summary & key facts 2021 124 citations

This clinical trial tested one session of deep and slow breathing (DSB) in 47 adults (22 older, 25 younger). After the single DSB session, high-frequency (HF) heart rate variability increased and self-reported state anxiety went down in both age groups. The rise in HF power was significantly larger in older…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Behavioral Health and Interventions Heart Rate Variability and Autonomic Control

Effect of long-term yoga training on autonomic function among the healthy adults

R Shobana, Maheshkumar Kuppusamy, Sankaralingam Thirupathy Venkateswaran, M Bagavad Geetha, R. Padmavathi

This small cross-sectional study compared 33 regular yoga practitioners with 35 non‑practitioners aged 17–30. The yoga group had a lower resting heart rate (about 69 vs 81 bpm) and a smaller blood‑pressure response on the sustained handgrip test (about 10.2 vs 16.3), differences the authors report as statistically significant. Other…

Heart Rate Variability and Autonomic Control Mindfulness and Compassion Interventions Stress Responses and Cortisol

Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation

Katie R. Hirsch, Abbie E. Smith‐Ryan, Erica J. Roelofs, Eric T. Trexler, Meredith G. Mock
Journal of Dietary Supplements Summary & key facts 2016 28 citations

This randomized, double-blind, placebo-controlled study tested a mushroom blend containing Cordyceps militaris (4 g/day) in 28 young, recreationally active adults. After one week there were no clear group differences on most lab tests, but analysis of confidence intervals showed time-to-exhaustion (TTE) increased by about 28 seconds in the mushroom group.…

Exercise and Physiological Responses Fungal Biology and Applications Muscle metabolism and nutrition

Occupational Burnout Is Linked with Inefficient Executive Functioning, Elevated Average Heart Rate, and Decreased Physical Activity in Daily Life – Initial Evidence from Teaching Professionals

Mia Pihlaja, Pipsa P. A. Tuominen, Jari Peräkylä, Kaisa M. Hartikainen
Brain Sciences Summary & key facts 2022 22 citations

Researchers studied 28 teaching professionals who wore a device for three days to record heart rate and steps and who completed questionnaires for burnout, depression, and everyday executive function. People who met criteria for burnout had more problems with executive functions in daily life, higher average heart rates, lower heart-rate…

Healthcare professionals’ stress and burnout Heart Rate Variability and Autonomic Control Stress and Burnout Research

The effect of slow breathing in regulating anxiety

Qian Luo, Xianrui Li, Jia Zhao, Jiang Qiu, Dongtao Wei
Scientific Reports Summary & key facts 2025 11 citations

This study tested how slow versus fast breathing affects anxiety and brain activity. Twenty-seven people did breathing and threat-uncertainty tasks while their brain activity was measured with EEG. Slow breathing reduced anxiety and led to different EEG patterns than fast breathing. In particular, slow breathing raised EEG power across several…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Heart Rate Variability and Autonomic Control Psychosomatic Disorders and Their Treatments

Impact of Himalayan Singing Bowls Meditation Session on Mood and Heart Rate Variability – An Observational Study

Saharsh Panchal, Fariburz Irani, Gunjan Y Trivedi

This small observational study checked mood and heart-rate measures before and after one 40-minute seated Himalayan singing bowl (HSB) sound-bath. After the session, 77 people reported higher positive affect and lower negative affect on the PANAS mood survey. A smaller group (17) filling the POMS survey reported less tension, anger,…

Heart Rate Variability and Autonomic Control Mindfulness and Compassion Interventions Sleep and related disorders
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