Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

15 papers

Antioxidative and Anti-Inflammatory Properties of Cannabidiol

Sinemyiz Atalay, Iwona Jarocka-Karpowicz, Elźbieta Skrzydlewska
Antioxidants Summary & key facts 2019 765 citations

This review says cannabidiol (CBD) is a non‑psychoactive cannabis compound that has antioxidant and anti‑inflammatory actions in lab and some clinical studies. CBD can act directly to neutralize reactive molecules and indirectly by changing cell signals and antioxidant enzymes. Experiments in cells and animals show CBD lowers markers of oxidative…

Cannabis and Cannabinoid Research Diet, Metabolism, and Disease GABA and Rice Research

Burnout: A Review of Theory and Measurement

Sergio Edú-Valsania, Ana Laguía, Juan A Moriano
PubMed Central (PMC) Summary & key facts 2022 716 citations

This open review explains burnout as a gradual response to long-term work stress that can harm thinking, feelings, and attitudes. It describes common causes, effects, ways to measure burnout, and actions to prevent or reduce it. The review highlights three main parts of burnout—emotional exhaustion, detachment or cynicism, and feeling…

Healthcare professionals’ stress and burnout Stress and Burnout Research Workplace Health and Well-being

Females with ADHD: An expert consensus statement taking a lifespan approach providing guidance for the identification and treatment of attention-deficit/ hyperactivity disorder in girls and women

Susan Young, Nicoletta Adamo, Bryndís Björk Ásgeirsdóttir, Polly Branney, Michelle Beckett, William Colley, et al.
BMC Psychiatry Summary & key facts 2020 431 citations

This ADDA article explains ADHD masking — when people hide or copy others to appear "normal." Masking can help someone function but often uses a lot of mental and emotional energy. The article says masking can delay diagnosis, cause burnout or mood problems, and may help explain why women are…

Attention Deficit Hyperactivity Disorder Autism Spectrum Disorder Research Child and Adolescent Psychosocial and Emotional Development

Prevalence and Early Identification of Autism Spectrum Disorder Among Children Aged 4 and 8 Years — Autism and Developmental Disabilities Monitoring Network, 16 Sites, United States, 2022

Kelly Shaw, Susan P. Williams, Mary Patrick, Miguel Valencia‐Prado, Maureen S. Durkin, Ellen M. Howerton, et al.
MMWR Surveillance Summaries Summary & key facts 2025 357 citations

This CDC report looked at how common autism spectrum disorder (ASD) was in 2022 at 16 U.S. sites and how early children were identified. Across those sites, 8-year-old children had ASD at a rate of 32.2 per 1,000 (about one in 31). The report found big differences by sex, race…

Autism Spectrum Disorder Research Child Nutrition and Feeding Issues Family and Disability Support Research

Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds

Mendel Friedman

This paper is a 2015 review that brings together many studies about the lion’s mane mushroom (Hericium erinaceus). It describes the mushroom’s chemical makeup, nutrients, food uses, and about 70 identified bioactive compounds. The review reports many claimed health effects seen in cell, animal, and some human studies—such as anti-inflammatory…

Fungal Biology and Applications Medicinal Plants and Bioactive Compounds Polysaccharides and Plant Cell Walls

A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol

Cinzia Citti, Pasquale Linciano, Fabiana Russo, Livio Luongo, Monica Iannotta, Sabatino Maione, et al.
Scientific Reports Summary & key facts 2019 200 citations

Researchers isolated a new natural cannabis compound called Δ9-tetrahydrocannabiphorol (Δ9-THCP) and its CBD counterpart (CBDP). In lab tests, Δ9-THCP bound very strongly to the human CB1 receptor (Ki = 1.2 nM) and caused THC-like effects in mice (less movement, pain relief, catalepsy, and lower body temperature). The authors say Δ9-THCP…

Biochemical Analysis and Sensing Techniques Cannabis and Cannabinoid Research GABA and Rice Research

Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production—A Review

Paulina Łysakowska, Aldona Sobota, Anna Wirkijowska
Molecules Summary & key facts 2023 194 citations

This review describes several medicinal mushrooms — including Lion's Mane, Reishi, Chaga, Cordyceps, Shiitake, and Turkey Tail — as low‑fat, low‑calorie foods that contain high levels of bioactive compounds (for example (1,3)(1,6)-β-d-glucans, triterpenes, phenolic compounds, and sterols). The review reports that these compounds have been linked in studies to anticancer,…

Fungal Biology and Applications Herbal Medicine Research Studies Medicinal Plants and Bioactive Compounds

Hericenones and erinacines: stimulators of nerve growth factor (NGF) biosynthesis inHericium erinaceus

Bingji Ma, Jinwen Shen, Hai‐You Yu, Yuan Ruan, Tingting Wu, Xu Zhao

This review surveys the chemical and biological literature dealing with the isolation, structural elucidation and bioactivity of hericenones and erinacines from the fruiting body and mycelium of Hericium erinaceus, concentrating on work that has appeared in the literature up to December 2009.

Fungal Biology and Applications Medicinal Plants and Bioactive Compounds Phytochemistry and Biological Activities

Emerging Therapeutic Potential of Cannabidiol (CBD) in Neurological Disorders: A Comprehensive Review

Kuldeep Singh, Bharat Bhushan, Dilip Kumar Chanchal, Satish Kumar Sharma, Ketki Rani, Manoj Kumar Yadav, et al.
Behavioural Neurology Summary & key facts 2023 55 citations

This 2023 review looks at many studies of cannabidiol (CBD) for brain and nerve conditions. It found lab, animal, and human evidence that CBD can reduce seizures and may protect nerve cells, lower inflammation, and act as an antioxidant. The review says results are promising for epilepsy, multiple sclerosis, Parkinson's…

Cannabis and Cannabinoid Research GABA and Rice Research Pancreatic function and diabetes

Maternity Blues: A Narrative Review

Valentina Tosto, Margherita Ceccobelli, Emanuela Lucarini, Alfonso Tortorella, Sandro Gerli, Fabio Parazzini, et al.

Maternity blues, also called baby blues, are short-lived mood changes after childbirth that can include tearfulness, irritability, anxiety, sleep and concentration problems. A recent review reports an overall prevalence of about 39% (studies ranged from 13.7% to 76%), but definitions and measurements vary widely. Symptoms usually start in the first…

Child and Adolescent Psychosocial and Emotional Development Infant Development and Preterm Care Maternal Mental Health During Pregnancy and Postpartum

Polysaccharide-K (PSK) in Cancer – Old Story, New Possibilities?

Cheng‐Cao Sun, Ann H. Rosendahl, X.D. Wang, Dan‐Hong Wu, R Andersson
Current Medicinal Chemistry Summary & key facts 2012 30 citations

Polysaccharide-K (PSK, also called Krestin) is a mushroom extract widely used as an additive in cancer treatment in Asia, especially Japan. Studies over about 40 years report anti-tumor effects in laboratory experiments and in living organisms for several cancer types, but researchers say the exact ways PSK works are not…

Cancer Treatment and Pharmacology Colorectal Cancer Treatments and Studies Fungal Biology and Applications

A Review of Historical Context and Current Research on Cannabis Use in India

Prakat Karki, Madhavi Rangaswamy

This review found that research on cannabis use in India is limited and often low quality. The authors identified 29 Indian studies (1986–2020) but said most had small, region‑specific samples, included only men, used weak methods, and relied on simple descriptive analyses. National surveys show cannabis use has risen, and…

Cannabis and Cannabinoid Research Child and Adolescent Psychosocial and Emotional Development Substance Abuse Treatment and Outcomes
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