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Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Cerebral blood flow

3 papers

The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level–Dependent Resting State Functional Connectivity

Robin Carhart‐Harris, Kevin Murphy, Robert Leech, David Erritzøe, Matthew B. Wall, B. Ferguson, et al.
Biological Psychiatry Summary & key facts 2014 181 citations

In a double-blind, placebo-controlled study, 25 healthy volunteers each took a single 100 mg dose of MDMA or placebo (one week apart) while their brains were scanned. MDMA produced clear increases in positive mood and caused localized decreases in blood flow in parts of the right medial temporal lobe (including…

Forensic Toxicology and Drug Analysis Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies

Molecular mechanisms underlying physical exercise-induced brain BDNF overproduction

Cefis, Marina, Chaney, Remi, Wirtz, Julien, et al.
www.frontiersin.org Summary & key facts 2023 91 citations

Many studies show that physical exercise helps brain health and can slow age-related thinking problems and lower the risk of some brain diseases and psychiatric disorders. A key part of these benefits is higher levels of the brain protein BDNF, which supports new brain cells and plasticity for learning and…

Axon Guidance and Neuronal Signaling Nerve injury and regeneration Neurogenesis and neuroplasticity mechanisms

Feeling Lightheaded: The Role of Cerebral Blood Flow

Johan Bresseleers, Ilse Van Diest, Steven De Peuter, Peter Verhamme, Omer Van den Bergh
Psychosomatic Medicine Summary & key facts 2010 20 citations

Researchers tested 33 healthy people to see how lightheadedness and brain blood flow are linked. During hyperventilation that lowered CO2, people's reports of lightheadedness matched drops in cerebral blood flow velocity (CBFv). After a few such episodes, a smell that had been paired with hyperventilation later triggered more lightheadedness and…

Heart Rate Variability and Autonomic Control Pain Management and Placebo Effect Psychosomatic Disorders and Their Treatments
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