Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.
23 papers
Some research suggests that whole-plant cannabis compounds (like THC, CBD, other cannabinoids, terpenes, and flavonoids) can interact so the plant’s effects differ from CBD alone. Healthline explains three CBD types — full-spectrum, broad-spectrum, and isolate — and notes legal, safety, and labeling limits. The article says there is evidence for…
The endocannabinoid system (ECS) is a widespread brain signaling system made of cannabinoid receptors, naturally made lipid messengers, and the enzymes that make and break those messengers. The two best-studied messengers are 2-AG and anandamide, and they are produced and degraded by different enzyme pathways. CB1 receptors are common in…
This review says cannabidiol (CBD) is a non‑psychoactive cannabis compound that has antioxidant and anti‑inflammatory actions in lab and some clinical studies. CBD can act directly to neutralize reactive molecules and indirectly by changing cell signals and antioxidant enzymes. Experiments in cells and animals show CBD lowers markers of oxidative…
This review describes the endocannabinoid system (ECS) as a widespread network of natural cannabinoids, cannabinoid receptors (mainly CB1 and CB2), and the enzymes that make and break those chemicals. The ECS helps shape brain development and adjusts how neurons communicate. The authors note that THC is the main psychoactive part…
This laboratory study found that cannabidiol (CBD), a non‑psychoactive compound from Cannabis sativa, reduced fat production and inflammation in human sebaceous (oil) gland cells. The effects were seen in cultured human sebocytes and in human skin organ cultures, where CBD blocked the fat‑making (lipogenic) actions of several compounds. These results…
The study heated Cannabis sativa extracts at 80, 95, 110, 130, and 145 °C for up to 60 minutes and measured acidic and neutral cannabinoids with an advanced UHPSFC/PDA‑MS lab method. Concentrations changed in an exponential way, which fits a first‑order (or pseudo‑first‑order) reaction model. The team calculated rate constants…
This is a short 1970 Nature paper by E. W. Gill, W. D. Paton and R. G. Pertwee that reports preliminary experiments on the chemistry and pharmacology of cannabis. The PubMed entry has no abstract, but its indexing shows the paper looked at drug effects and toxicity, and at topics…
In rats and mice that had brain lesions used to model Parkinson's disease, the plant compound Δ9-THCV reduced movement problems after a single dose and, with repeated dosing, reduced loss of dopamine-producing neurons in the brain region called the substantia nigra. Some effects seem linked to antioxidant actions and, in…
Researchers isolated a new natural cannabis compound called Δ9-tetrahydrocannabiphorol (Δ9-THCP) and its CBD counterpart (CBDP). In lab tests, Δ9-THCP bound very strongly to the human CB1 receptor (Ki = 1.2 nM) and caused THC-like effects in mice (less movement, pain relief, catalepsy, and lower body temperature). The authors say Δ9-THCP…
This review explains that terpenes are the main parts of cannabis essential oils and give cannabis its smells. Hundreds of terpenes have been identified, and they shape how different cannabis types smell, how consumers experience them, and their market value. The authors say terpenes are made and stored in glandular…
Cannabis makes more than 120 “minor” cannabinoids that appear in smaller amounts than THC and CBD and come from a parent compound called cannabigerolic acid (CBGA). Early lab and clinical work shows these minor cannabinoids can activate or block many biological targets (for example CB1 and CB2 receptors, TRP channels,…
This review explains how the main cannabis chemicals, especially THC and CBD, act in the body and how the body absorbs and breaks them down. THC and CBD bind to cannabinoid receptors (CB1 and CB2) in the brain and other organs. Inhaling THC delivers it to blood and brain fast…
