Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

3 papers

Esketamine combined with a mindfulness-based intervention for individuals with alcohol problems

E.M. Van Gent, J. Bryan, M Cleary, Tegan I Clarke, Harry D Holmwood, Rania O Nassereddine, et al.
Journal of Psychopharmacology Summary & key facts 2024 13 citations

This small, double-blind pilot trial gave 28 people with alcohol problems either a sublingual esketamine film (115.1 mg) or a vitamin C placebo while they did two weeks of daily mindfulness practice. Compared with placebo, esketamine increased people’s psychological engagement with the meditation, produced stronger mystical and dissociative experiences, and…

Mindfulness and Compassion Interventions Treatment of Major Depression Tryptophan and brain disorders

Multimodal neurophenomenology of advanced concentration absorption meditation: An intensively sampled case study of Jhana

Avijit Chowdhury, Marta Bianciardi, Eric Chapdelaine, Omar S Riaz, Christopher Timmermann, Remko van Lutterveld, et al.
NeuroImage Summary & key facts 2024 10 citations

Researchers scanned the brain activity of one very experienced meditator (more than 23,000 hours of practice) while they entered deep concentration states called jhanas. They used two brain-measuring tools — fMRI, which shows which brain areas are communicating, and EEG, which records electrical rhythms — and also had the person…

Memory and Neural Mechanisms Mindfulness and Compassion Interventions Sleep and Wakefulness Research

Mindful eating and food intake: Effects and mechanisms of action.

Lana Seguias, Danielle Ferriday, Elanor C. Hinton, Tina McCaw, Katy Tapper

The authors ran four lab studies on "sensory eating," which means paying close attention to a food's look, smell, texture, and taste while you eat. In each study people ate a small high-calorie snack either with sensory eating or as usual, and 5–15 minutes later they were offered larger snack…

Eating Disorders and Behaviors Mindfulness and Compassion Interventions
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