Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.
Treatment-resistant depression means depression that does not get better after usual treatments. Scientists do not all agree on one clear definition, which makes it hard to know exactly how common it is or which treatments work best. Using the definition that regulators often use, about 30% of people with depression…
In an open-label pilot study, 32 adults (ages 22–72; 53% female) with ongoing suicidal thoughts took low-dose oral ketamine for six weeks (starting at 0.5 mg/kg and titrated up to 3.0 mg/kg). Average scores on the Beck Scale for Suicide Ideation fell from a high level before treatment to below…
