Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

17 papers

The Efficacy of Cognitive Behavioral Therapy: A Review of Meta-analyses

Stefan G. Hofmann, Anu Asnaani, Imke J. J. Vonk, Alice T. Sawyer, Angela Fang
Cognitive Therapy and Research Summary & key facts 2012 3,230 citations

This 2012 paper reviewed meta-analyses on cognitive behavioral therapy (CBT). The authors found 269 meta-analytic studies and examined a representative sample of 106 reviews across many problems. They reported the strongest support for CBT for anxiety disorders, somatoform disorders, bulimia, anger control problems, and general stress. The paper concluded the…

Child and Adolescent Psychosocial and Emotional Development Personality Disorders and Psychopathology Psychotherapy Techniques and Applications

Delivering Cognitive Behavior Therapy to Young Adults With Symptoms of Depression and Anxiety Using a Fully Automated Conversational Agent (Woebot): A Randomized Controlled Trial

Kathleen Kara Fitzpatrick, Alison Darcy, Molly Vierhile
JMIR Mental Health Summary & key facts 2017 2,318 citations

This small randomized trial tested a fully automated text-based conversational agent called Woebot as a way to deliver cognitive behavioral therapy to college-age young adults with symptoms of depression and anxiety. Over 2 weeks, the Woebot group (n=34) showed a statistically larger drop in depression scores (PHQ-9) than an information-only…

Digital Mental Health Interventions Impact of Technology on Adolescents Mental Health Research Topics

Mindfulness-Based Interventions for Anxiety and Depression

Stefan G Hofmann, Angelina F Gómez
PubMed Central (PMC) Summary & key facts 2017 706 citations

Mindfulness-based interventions (MBIs), especially Mindfulness-Based Stress Reduction (MBSR) and Mindfulness-Based Cognitive Therapy (MBCT), teach people to pay nonjudgmental attention to the present moment. Reviews and randomized trials show MBIs can reduce anxiety and depression symptom severity across many groups, often doing better than non-evidence treatments or active controls and performing…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Mindfulness and Compassion Interventions

A Randomized Controlled Effectiveness Trial of Acceptance and Commitment Therapy and Cognitive Therapy for Anxiety and Depression

Evan M. Forman, James D. Herbert, Ethan Moitra, Peter D. Yeomans, Pamela A. Geller
Behavior Modification Summary & key facts 2007 682 citations

The source explains what Acceptance and Commitment Therapy (ACT) is and reports research comparing ACT with cognitive therapy (CT). In a randomized trial of 101 outpatients with moderate to severe anxiety or depression, people assigned to ACT or to CT showed large, similar improvements in depression, anxiety, daily functioning, quality…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Complementary and Alternative Medicine Studies Mindfulness and Compassion Interventions

Treating PTSD: A Review of Evidence-Based Psychotherapy Interventions

Laura E. Watkins, Kelsey Sprang, Barbara O. Rothbaum

Posttraumatic stress disorder (PTSD) is a chronic, often debilitating mental health disorder that may develop after a traumatic life event. Fortunately, effective psychological treatments for PTSD exist. In 2017, the Veterans Health Administration and Department of Defense (VA/DoD) and the American Psychological Association (APA) each published treatment guidelines for PTSD,…

Posttraumatic Stress Disorder Research Resilience and Mental Health Traumatic Brain Injury Research

Cognitive-behavioral therapy for anxiety disorders: an update on the empirical evidence

Antonia N. Kaczkurkin, Edna B. Foa

This article reviews a large body of research on cognitive-behavioral therapy (CBT) for anxiety disorders. It focuses on two common CBT methods — exposure therapy and cognitive therapy — and concludes that CBT generally works for many anxiety problems. The authors also say it is hard to compare active CBT…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Mental Health Research Topics

Cognitive behavioral interventions for alcohol and drug use disorders: Through the stage model and back again.

Kathleen M. Carroll, Brian D. Kiluk

Cognitive behavioral therapy (CBT) is one of the most-studied treatments for alcohol and drug problems. Reviews of many trials find a small but real average benefit: a meta-analysis of 53 controlled trials reported an effect size of g = 0.15 and estimated that 58% of people given CBT did better…

Child and Adolescent Psychosocial and Emotional Development Mental Health Research Topics Substance Abuse Treatment and Outcomes

Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety

Leonardo Tozzi, Xue Zhang, Adam Pines, Alisa Olmsted, Emily Zhai, Esther T. Anene, et al.
Nature Medicine Summary & key facts 2024 162 citations

The researchers created personalized brain circuit scores from both task-free and task-evoked fMRI scans in a large group of people with depression and anxiety. Using a standardized processing method, they measured 41 circuit features across six brain systems and used those measures to define six distinct “biotypes.” These biotypes showed…

Functional Brain Connectivity Studies Mental Health Research Topics Treatment of Major Depression

Cognitive behavior therapy for chronic subjective dizziness: a randomized, controlled trial

Sarah Edelman, Alison Mahoney, Phillip D. Cremer

This randomized, controlled trial tested a brief cognitive behavioral therapy (CBT) program for 41 patients with chronic subjective dizziness. The program was three weekly sessions led by a clinical psychologist and used psychoeducation, behavioral experiments, exposure, and attention refocusing. After treatment, patients showed large, significant reductions in dizziness-related disability, physical…

Glaucoma and retinal disorders Hearing, Cochlea, Tinnitus, Genetics Vestibular and auditory disorders

Effect of Internet vs Face-to-Face Cognitive Behavior Therapy for Health Anxiety: A Randomized Noninferiority Clinical Trial

Erland Axelsson, Erik Andersson, Brjánn Ljótsson, Daniel Björkander, Maria Hedman-Lagerlöf, Erik Hedman-Lagerlöf
PubMed Central (PMC) Summary & key facts 2020 116 citations

This randomized noninferiority clinical trial examines the effect of internet-delivered vs face-to-face cognitive behavior therapy especially in light of resources, access, and cost.

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Digital Mental Health Interventions Psychosomatic Disorders and Their Treatments

Cognitive-Behavioral Treatments for Anxiety and Stress-Related Disorders

Joshua Curtiss, Daniella Levine, Ilana Ander, Amanda W. Baker

This review says cognitive-behavioral therapy (CBT) is a well-researched, first-line treatment for anxiety and related disorders. CBT is structured and often manualized, usually delivered weekly for a limited period (about 12–16 weeks) and sometimes followed by booster sessions. Core CBT methods are cognitive techniques (like identifying thinking traps, cognitive restructuring,…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Digital Mental Health Interventions

Efficacy of Cognitive Behavioral Therapy With and Without Medication for Adults With ADHD: A Randomized Clinical Trial

Mariya V. Cherkasova, L French, Cassidy A. Syer, Lorne S. Cousins, Harry Galina, Yasaman Ahmadi-Kashani, et al.
Journal of Attention Disorders Summary & key facts 2016 54 citations

This randomized clinical trial tested 12 sessions of manualized group cognitive behavioral therapy (CBT) with individual coaching in 88 adults with ADHD. Participants were randomly assigned to CBT alone (n = 46) or CBT plus medication (n = 42). The combined treatment produced greater improvements in ADHD symptoms, organizational skills,…

Attention Deficit Hyperactivity Disorder Behavioral and Psychological Studies Neural and Behavioral Psychology Studies
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