Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

3 papers

Impact of anxiety on prefrontal cortex encoding of cognitive flexibility

Junchol Park, Bita Moghaddam
Neuroscience Summary & key facts 2016 221 citations

This review looks at studies in humans and animals that link anxiety and stress with poorer cognitive flexibility — the ability to change strategies when rules or goals change. It describes evidence that the prefrontal cortex (PFC) is central to flexible behavior, that anxiety or PFC disruptions are associated with…

Memory and Neural Mechanisms Neural and Behavioral Psychology Studies Stress Responses and Cortisol

Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting

Luisa Prochazkova, Dominique P. Lippelt, Lorenza S. Colzato, Martin Kuchař, Zsuzsika Sjoerds, Bernhard Hommel
Psychopharmacology Summary & key facts 2018 176 citations

In a natural, open-label study at a microdosing event, researchers tested people before and while they expected the effects of a psychedelic truffle microdose. They found better performance on a task that measures convergent thinking and on a task that measures divergent thinking. A short test of fluid intelligence did…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies

Four Weeks of Hericium erinaceus Supplementation Does Not Impact Markers of Metabolic Flexibility or Cognition

Corey D. Grozier, Victor A Alves, Lauren G. Killen, Jeffrey D. Simpson, Eric K. O’Neal, Hunter S. Waldman

Researchers tested whether taking 10 g per day of Hericium erinaceus (Lion's Mane mushroom) for four weeks changes how the body uses fuel during exercise or affects thinking in a college-age group. In a single-blind, placebo-controlled trial, 24 participants ate muffins with either the mushroom or a placebo and completed…

Exercise and Physiological Responses Fungal Biology and Applications Muscle metabolism and nutrition
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