Frontier mental health research: psychedelics & drug studies

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12 papers

Association between depression and anemia in otherwise healthy adults

Hélène Vulser, Emmanuel Wiernik, Nicolas Hoertel, Fred B. Thomas, Bruno Pannier, Sébastien Czernichow, et al.
Acta Psychiatrica Scandinavica Summary & key facts 2016 129 citations

In healthy adults from the general population, we found a significant and robust association between depression and anemia. Further studies are needed to assess the longitudinal relationship between both conditions and determine the mechanisms underlying this association.

Dialysis and Renal Disease Management Erythropoietin and Anemia Treatment Iron Metabolism and Disorders

Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial

Colleen Loo, Nick Glozier, Dávid Barton, Bernhard T. Baune, Natalie Mills, Paul B. Fitzgerald, et al.

Researchers tested repeated subcutaneous (under-the-skin) injections of racemic ketamine in people whose depression had not improved after at least two antidepressant trials. People got injections twice a week for 4 weeks and neither participants nor the raters knew which drug they were getting. When the study allowed higher, response-guided ketamine…

Mental Health Research Topics Treatment of Major Depression Tryptophan and brain disorders Ketamine

Racial/ethnic differences in prevalence of hallucinogen use by age cohort: Findings from the 2018 National Survey on Drug Use and Health

Zoe W. Jahn, Joel Lopez, Sara de la Salle, Sonya C. Faber, Monnica T. Williams
Journal of Psychedelic Studies Summary & key facts 2021 35 citations

Researchers analyzed answers from about 56,000 people in a 2018 U.S. health survey to see who has used hallucinogens. They found about 16% had tried a hallucinogen at least once, and about 2% had used one in the past year. Use was higher among White and multiracial people and lowest…

Biochemical Analysis and Sensing Techniques Cannabis and Cannabinoid Research Psychedelics and Drug Studies

The association of burnout with work absenteeism and the frequency of thoughts in leaving their job in a cohort of healthcare workers during the COVID-19 pandemic

Cerina Lee, Thanh‐Huyen T. Vu, John A. Fuller, Melanie E. Freedman, Jacqueline Bannon, John T. Wilkins, et al.
Frontiers in Health Services Summary & key facts 2023 26 citations

Overall, this study cohort showed a positive association between burnout scores and unplanned work absenteeism (and frequency of thoughts in leaving job) during the COVID-19 pandemic. More research is needed to support healthcare worker well-being during times of stress and direct solutions to addressing unplanned absenteeism in the light of…

COVID-19 and Mental Health Healthcare professionals’ stress and burnout Workplace Health and Well-being

Neurogenetic analysis of childhood disintegrative disorder

Abha R. Gupta, Alexander Westphal, Daniel Y.‐J. Yang, Catherine Sullivan, Jeffrey Eilbott, Samir Zaidi, et al.
Molecular Autism Summary & key facts 2017 24 citations

This document presents an “emerging” 2-item clinician-rated measure from the American Psychiatric Association to record how much social communication problems and restricted interests/repetitive behaviors interfere with a person’s functioning. Each domain is rated by a clinician for the past seven days on a 4-point scale from 0 (None) to 3…

Autism Spectrum Disorder Research Genetics and Neurodevelopmental Disorders Genomic variations and chromosomal abnormalities

Effects of Psychedelics in Older Adults: A Prospective Cohort Study

Hannes Kettner, Leor Roseman, Adam Gazzaley, Robin Carhart‐Harris, Lorenzo Pasquini

Researchers followed 62 older adults (age 60 and up) and 62 younger adults who planned to take part in guided psychedelic group sessions. People in both age groups reported better well-being in the weeks after the sessions, but older adults experienced weaker immediate drug effects during the sessions. For older…

Biochemical Analysis and Sensing Techniques Chemical synthesis and alkaloids Psychedelics and Drug Studies Ayahuasca LSD

Relationship between depressive symptoms and anemia among the middle-aged and elderly: a cohort study over 4-year period

Congqi Liu, Ruihao Zhou, Xilin Peng, Tao Zhu, Wei Wei, Xuechao Hao
BMC Psychiatry Summary & key facts 2023 13 citations

This study used China’s CHARLS data from 2011 and 2015 to look at people aged 45 and older. In 10,179 people at baseline, higher depressive symptom scores were linked to lower hemoglobin and to having anemia. Over 4 years (5,887 people followed), people with depressive symptoms had higher odds of…

Health disparities and outcomes Maternal Mental Health During Pregnancy and Postpartum Optimism, Hope, and Well-being

Risk of suicide and all-cause death in patients with mental disorders: a nationwide cohort study

Hyewon Kim, Jin‐Hyung Jung, Kyungdo Han, Hong Jin Jeon
Molecular Psychiatry Summary & key facts 2025 9 citations

This large South Korean study followed 3,951,398 adults for an average of 11.1 years to compare deaths in people with and without recorded mental disorders. After adjusting for age, sex, health conditions, income, smoking, drinking and physical activity, people with mental disorders had higher rates of suicide and higher overall…

Bipolar Disorder and Treatment Mental Health Treatment and Access Suicide and Self-Harm Studies

Cannabis use and sleep problems among young adults by mental health status: A prospective cohort study

Claire Walsh, Ekkehard Euler, A. Lauren, Amy Zheng, Sandrah P. Eckel, Bernard L. Harlow, et al.
Addiction Summary & key facts 2024 5 citations

This study followed 1,926 young adults (age 20–23) in Southern California from 2020 to 2021 to see how cannabis use related to later sleep problems. The researchers found that frequent cannabis use (≥20 days/month) was linked with worse sleep for people without anxiety or depression, but linked with slightly better…

Cannabis and Cannabinoid Research Sleep and related disorders Sleep and Wakefulness Research

Reward-related self-agency is disturbed in depression and anxiety

Marishka Mehta, Soojung Na, Xiaosi Gu, James W. Murrough, Laurel Morris
PLoS ONE Summary & key facts 2023 5 citations

Researchers tested a new task that measures how people feel they caused rewards or losses. They studied 52 healthy adults and 20 adults with depression or anxiety in person, and 254 people online. Healthy people felt more personal control after wins than after losses. People with depression or anxiety showed…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Neural and Behavioral Psychology Studies Psychosomatic Disorders and Their Treatments

UK medical cannabis registry: A clinical outcome analysis of medical cannabis therapy in chronic pain patients with and without co‐morbid sleep impairment

Ishita Datta, Simon Erridge, Carl Holvey, Ross Coomber, Rahul Guru, Wendy Holden, et al.
Pain Practice Summary & key facts 2024 2 citations

This study looked at 1,139 chronic pain patients in a UK medical cannabis registry and compared those with poor sleep to those without. Both groups reported improvements in pain, quality of life, anxiety, and other measures over 1, 3, 6 and 12 months after starting cannabis‐based medicines. People with sleep…

Cannabis and Cannabinoid Research Sleep and related disorders Sleep and Wakefulness Research
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