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19 papers
In a small, controlled study of 18 people with treatment-resistant major depression, a single intravenous dose of the NMDA receptor antagonist ketamine (0.5 mg/kg) produced rapid drops in depression scores. Improvement began within about 2 hours and remained statistically significant compared with placebo for up to 1 week. The study…
This fact sheet reports that people with eating disorders have higher death rates than the general population. Death rates are highest for anorexia nervosa (AN). Bulimia nervosa (BN) and eating disorder not otherwise specified (EDNOS) have similar death rates. The sheet says older age at assessment was linked to higher…
This study followed a nationally representative group of U.S. children who started kindergarten in 1998–99 to track ADHD diagnosis from kindergarten through eighth grade. It found that racial and ethnic minority children were less likely than white children to be diagnosed by kindergarten and that these differences continued through eighth…
In healthy adults from the general population, we found a significant and robust association between depression and anemia. Further studies are needed to assess the longitudinal relationship between both conditions and determine the mechanisms underlying this association.
This meta-analysis of observational studies found that higher exposure to green space was linked with slightly lower odds of depression and possibly lower odds of anxiety. A 10% increase in the amount of green space was associated with lower odds of depression (OR 0.963; 95% CI 0.948–0.979) and with a…
This large review combined 441 randomized trials with 33,881 patients to measure how many people show a clear response to psychotherapy across eight mental disorders. Response was defined as at least a 50% reduction in symptoms from before to after treatment. Pooled response rates were modest (for example, about 42%…
In a study of 1,298,890 women in Quebec, 5,169 who had been hospitalized for anorexia nervosa were followed up to March 31, 2018. Women with hospital-treated anorexia had higher death rates over time than women without anorexia. The higher risk was strongest in the first 10 years after hospitalization and…
This population study used Taiwan's national health insurance records to compare adults with iron deficiency anemia (IDA) to matched people without IDA from 2000–2013. After adjusting for other factors, people with IDA had a higher risk of being diagnosed with psychiatric disorders (adjusted hazard ratio 1.52, 95% CI 1.45–1.59). The…
Self-reported history of iron-deficiency anemia was associated with self-reported history of depression. Furthermore, self-reported history of iron-deficiency anemia was associated with higher psychological distress.
This review combined 17 studies of deep brain stimulation (DBS) for people with treatment-resistant depression. Across studies, about 56% of patients showed a clinical response and 35% reached remission, while 14% later had recurrence. Adverse events were common (about 67%), and the two randomized trials did not show a clear,…
This review combined 65 randomized trials with 5,048 adults who had generalized anxiety disorder. The authors found that cognitive behavioral therapy (CBT) was linked with better short-term and long-term outcomes than treatment as usual. Third‑wave CBTs and relaxation therapy were linked with short-term benefits, but after removing studies judged to…
This systematic review and meta-analysis pooled seven randomized trials with 1760 adults seen in emergency departments (search to 21 May 2021). It found no clear difference in short-term pain scores between intranasal (IN) ketamine and IV analgesics or placebo at 5, 15, 25, 30, and 60 minutes. The need for…
