Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

7 papers

Effects of physical exercise on anxiety, depression, and sensitivity to stress

Peter Salmon
Clinical Psychology Review Summary & key facts 2001 1,332 citations

This 2001 review looked at studies on exercise, anxiety, depression, and stress. It found that short-term emotional effects of exercise are mixed, but many cross-sectional and longitudinal studies report that regular aerobic exercise training reduces anxiety and depression symptoms and may protect against the harmful effects of stress. The clearest…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Eating Disorders and Behaviors Mental Health Research Topics

A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial)

Jacka, Felice N., O’Neil, Adrienne, Opie, Rachelle, et al.
SpringerLink Summary & key facts 2017 1,000 citations

This 12-week randomised trial tested a structured dietary program (a modified Mediterranean-style diet) against a social-support control in adults with moderate to severe major depression. Sixty-seven people were randomised (33 to diet, 34 to control). The diet group showed larger drops in depressive symptoms on the MADRS scale at 12…

Diet and metabolism studies Eating Disorders and Behaviors Nutritional Studies and Diet

Effectiveness of physical activity interventions for improving depression, anxiety and distress: an overview of systematic reviews

Ben Singh, Tim Olds, Rachel Curtis, Dorothea Dumuid, Rosa Virgara, Amanda Watson, et al.
PubMed Summary & key facts 2023 784 citations

This umbrella review pooled evidence from 97 systematic reviews (1,039 randomized trials, 128,119 participants) to examine whether physical activity affects symptoms of depression, anxiety and psychological distress in adults. Overall, physical activity produced medium-sized reductions in symptoms (median effect size for depression = -0.43, for anxiety = -0.42; distress effect…

Behavioral Health and Interventions Eating Disorders and Behaviors Physical Activity and Health

Depression and eating disorders: Treatment and course

David Mischoulon, Kamryn T. Eddy, Aparna Keshaviah, Diana Dinescu, Stephanie L. Ross, Andrea E. Kass, et al.
Journal of Affective Disorders Summary & key facts 2010 137 citations

This long study followed 246 treatment-seeking women with anorexia or bulimia for about 9 years. Major depression was common and often long-lasting: 70% of those who had depression recovered, but 65% of those who recovered later relapsed. Recovery chances varied by type of eating disorder, and time on antidepressants was…

Eating Disorders and Behaviors Mental Health Research Topics Treatment of Major Depression

Mindful awareness in body-oriented therapy as an adjunct to women’s substance use disorder treatment: a pilot feasibility study

Cynthia Price, Elizabeth A. Wells, Dennis M. Donovan, Tessa Rue
PubMed Summary & key facts 2012 90 citations

This small randomized pilot study tested a therapy called Mindful Awareness in Body-Oriented Therapy (MABT) as an extra treatment for women in substance use disorder (SUD) care. Forty-six women were enrolled and those in the MABT group received eight weekly one-on-one sessions in addition to usual care. At the main…

Eating Disorders and Behaviors Mindfulness and Compassion Interventions Psychosomatic Disorders and Their Treatments

An examination of weight bias among treatment-seeking obese patients with and without binge eating disorder

Rachel D. Barnes, Valentina Ivezaj, Carlos M. Grilo
General Hospital Psychiatry Summary & key facts 2013 32 citations

This paper is a systematic review of research on adults that looked at how eating disorders, body image, emotions, and self-esteem are linked. The authors searched three databases for papers from 2010–2024, screened 1,117 records, and included 6 studies, most of which had mostly female participants. The studies commonly found…

Eating Disorders and Behaviors Obesity and Health Practices Obesity, Physical Activity, Diet

A case series of group-based ketamine-assisted psychotherapy for patients in residential treatment for eating disorders with comorbid depression and anxiety disorders

Reid Robison, Adèle Lafrance, Madeline Brendle, Michelle Smith, Claire E. Moore, Sachin Ahuja, et al.
Journal of Eating Disorders Summary & key facts 2022 31 citations

This small case series tested group-based ketamine-assisted psychotherapy (G-KAP) with five women in a residential eating-disorder program. Participants got weekly intramuscular ketamine in a group for 4 weeks. Four of five showed clinically meaningful drops in depression scores after the final session, and two of five showed clinically meaningful drops…

Eating Disorders and Behaviors Treatment of Major Depression Tryptophan and brain disorders
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