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Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Cannabis and Cannabinoid Research Diabetes mellitus

4 papers

Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study

Khalid Jadoon, S. Ratcliffe, David A. Barrett, E. Louise Thomas, Colin Stott, Jimmy D. Bell, et al.
Diabetes Care Summary & key facts 2016 246 citations

This was a small, randomized, double-blind, placebo-controlled 13-week pilot trial of two nonpsychoactive cannabis-related compounds (cannabidiol, CBD, and tetrahydrocannabivarin, THCV) in 62 people with type 2 diabetes who were not using insulin. Participants were assigned to CBD, THCV, two CBD/THCV combination doses, or placebo. Compared with placebo, THCV lowered fasting…

Cannabis and Cannabinoid Research Diet, Metabolism, and Disease Pancreatic function and diabetes

The cannabinoid Δ9-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity

Edward T. Wargent, Mohamed S. Zaïbi, Cristoforo Silvestri, David C. Hislop, Claire J. Stocker, Colin Stott, et al.
Nutrition and Diabetes Summary & key facts 2013 102 citations

This study tested the cannabinoid THCV in two kinds of obese mice and in insulin-resistant liver and muscle cells. THCV did not change food intake or body weight, but it briefly raised energy use and improved how the animals handled glucose. In obese mice, THCV improved glucose tolerance and insulin…

Cannabis and Cannabinoid Research Neurotransmitter Receptor Influence on Behavior Pancreatic function and diabetes

Δ9-Tetrahydrocannabivarin (THCV): a commentary on potential therapeutic benefit for the management of obesity and diabetes

Amos Olusegun Abioye, Olubukola Ayodele, Aleksandra Marinkovic, Risha Patidar, Adeola Akinwekomi, Adekunle Sanyaolu
Journal of Cannabis Research Summary & key facts 2020 80 citations

THCV is a cannabis compound that does not cause the “high” linked to THC. In animal studies it lowered appetite, increased feelings of fullness, and raised energy use, and some small studies in people with type 2 diabetes found lower fasting blood sugar versus placebo. Researchers say these findings make…

Cannabis and Cannabinoid Research Diet, Metabolism, and Disease Neurotransmitter Receptor Influence on Behavior

The role of tetrahydrocannabivarin (THCV) in metabolic disorders: A promising cannabinoid for diabetes and weight management

Stanley A. Mendoza
AIMS neuroscience Summary & key facts 2025 5 citations

This article reviews evidence that tetrahydrocannabivarin (THCV), a non-psychoactive compound from Cannabis sativa, may help with obesity and type 2 diabetes. In lab and animal studies THCV reduced appetite, improved insulin sensitivity and glucose uptake, lowered fat buildup, and boosted energy function in fat and liver cells. Early human trials…

Cannabis and Cannabinoid Research Diet, Metabolism, and Disease Liver Disease Diagnosis and Treatment
Summaries and links are for general information and education only. They are not a substitute for reading the original publication or for professional medical, legal, or other advice. Always refer to the linked source for the full study.