Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

2 papers

The cannabinoid Δ9-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity

Edward T. Wargent, Mohamed S. Zaïbi, Cristoforo Silvestri, David C. Hislop, Claire J. Stocker, Colin Stott, et al.
Nutrition and Diabetes Summary & key facts 2013 102 citations

This study tested the cannabinoid THCV in two kinds of obese mice and in insulin-resistant liver and muscle cells. THCV did not change food intake or body weight, but it briefly raised energy use and improved how the animals handled glucose. In obese mice, THCV improved glucose tolerance and insulin…

Cannabis and Cannabinoid Research Neurotransmitter Receptor Influence on Behavior Pancreatic function and diabetes

Δ9-Tetrahydrocannabivarin (THCV): a commentary on potential therapeutic benefit for the management of obesity and diabetes

Amos Olusegun Abioye, Olubukola Ayodele, Aleksandra Marinkovic, Risha Patidar, Adeola Akinwekomi, Adekunle Sanyaolu
Journal of Cannabis Research Summary & key facts 2020 80 citations

THCV is a cannabis compound that does not cause the “high” linked to THC. In animal studies it lowered appetite, increased feelings of fullness, and raised energy use, and some small studies in people with type 2 diabetes found lower fasting blood sugar versus placebo. Researchers say these findings make…

Cannabis and Cannabinoid Research Diet, Metabolism, and Disease Neurotransmitter Receptor Influence on Behavior
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