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43 papers
This study reviewed surveys and used global models to measure how the COVID-19 pandemic changed rates of major depressive disorder and anxiety disorders in 2020. It found that places with higher COVID-19 infection rates and bigger drops in movement had larger increases in these disorders. The authors estimate about 53.2…
This review looks at how large disasters, including COVID-19, affect mental health and discusses digital solutions. The authors report higher rates of anxiety, depression and posttraumatic stress after disasters and give survey numbers from the COVID-19 outbreak. They say many countries have limited mental health services that could be stretched…
This paper is a careful review of research about treatment-resistant depression. The authors looked through medical studies to see how doctors define this kind of depression, what makes it hard to assess, and which treatments have been tried. They describe drug strategies like adding lithium or thyroid hormone, switching antidepressant…
Researchers gave different psychedelic drugs to mice and found the drugs could reopen a window of brain plasticity used for learning social rewards. This reopened window went along with changes in a social hormone system in a key reward area of the brain and with changes in genes that control…
This review found that Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) share many symptoms and similar biological changes. People with both conditions often have long-lasting fatigue, thinking problems, sleep disruption, pain, post-exertional worsening, and signs of problems in the brain, autonomic nervous system, heart, lungs, immune system, gut microbiome,…
This chapter explains three ways people think about health. It says the best view — the "complete state" — includes both the lack of disease and the presence of positive mental capacities and functioning. The author reviews studies that support using this complete-state view for mental health and suggests that…
Researchers tested deep brain stimulation (DBS) in a small group of people whose depression did not get better with usual treatments. They used an implanted device that both delivered stimulation to the subcallosal cingulate (a brain area linked to mood) and recorded brain electrical signals. Around 9 out of 10…
This webpage explains how DoktorABC offers medical cannabis services in Germany. You fill an online medical questionnaire, a licensed doctor reviews it, and may issue a prescription. The page also describes costs, delivery times, legal status, types of products, common effects of THC and CBD, and possible side effects.
This study measured health-related quality of life (HRQoL) in Danish patients with ME/CFS using the EQ-5D-3L tool and found their scores were much lower than the general population and lower than 20 other conditions. The average (unadjusted) EQ-5D-3L score for the ME/CFS group was 0.47, while the population average was…
In rats and mice that had brain lesions used to model Parkinson's disease, the plant compound Δ9-THCV reduced movement problems after a single dose and, with repeated dosing, reduced loss of dopamine-producing neurons in the brain region called the substantia nigra. Some effects seem linked to antioxidant actions and, in…
Past large trials found that using combined estrogen and progestin was linked to higher heart-related risk, and hormone therapy (HT) use fell a lot afterward. In the last 20 years, research shows that when HT starts (age and time since menopause) and how it is given (route) affect heart disease…
This systematic review looked at 33 studies about social anxiety during the COVID-19 pandemic. The studies suggest social anxiety increased in the general population. Women and people with low incomes appeared more likely to report higher social anxiety. Other links to higher social anxiety included poor coping, weaker social support,…
