Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

3 papers

Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double‐blind placebo‐controlled clinical trial

Koichiro Mori, Satoshi Inatomi, Kenzi Ouchi, Yoshihito Azumi, Takashi Tuchida
Phytotherapy Research Summary & key facts 2008 249 citations

In a small, double-blind, placebo-controlled trial of Japanese adults aged 50–80 with mild cognitive impairment, 30 people were randomly assigned to take Yamabushitake (an edible mushroom) or placebo for 16 weeks. The mushroom group took four 250 mg tablets three times a day and showed higher scores on a cognitive…

Fungal Biology and Applications Ginkgo biloba and Cashew Applications Medicinal Plants and Bioactive Compounds

The Acute and Chronic Effects of Lion’s Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study

Sarah Docherty, Faye L. Doughty, Ellen Smith
Nutrients Summary & key facts 2023 32 citations

This small, randomized, double-blind, placebo-controlled pilot trial tested 1.8 g daily of Lion’s Mane (Hericium erinaceus) in healthy young adults (ages 18–45, mean 26.35). After a single dose, participants given Lion’s Mane were faster on the Stroop task 60 minutes later (p = 0.005). After 28 days there was a…

Bee Products Chemical Analysis Healthcare and Venom Research Pain Mechanisms and Treatments

Acute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study

Surendran, Geyan, Saye, Jake, Binti Mohd Jalil, Syahira, et al.
www.frontiersin.org Summary & key facts 2025 4 citations

This double-blind, randomised, placebo-controlled study tested a single (acute) dose of a standardized extract from the Lion’s Mane mushroom (fruiting body) in healthy younger adults. The study did not find a clear overall benefit for thinking skills or mood compared with placebo. The authors say any small benefits might only…

Fungal Biology and Applications Medicinal Plants and Bioactive Compounds Pharmacological Effects of Natural Compounds
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