Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

97 papers

Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic

COVID-19 Mental Disorders Collaborators
PubMed Central (PMC) Summary & key facts 2021 5,135 citations

This study reviewed surveys and used global models to measure how the COVID-19 pandemic changed rates of major depressive disorder and anxiety disorders in 2020. It found that places with higher COVID-19 infection rates and bigger drops in movement had larger increases in these disorders. The authors estimate about 53.2…

COVID-19 and Mental Health Health disparities and outcomes Long-Term Effects of COVID-19

The World Health Organization Adult ADHD Self-Report Scale (ASRS): a short screening scale for use in the general population

Ronald C. Kessler, Lenard A. Adler, Minnie Ames, Olga Demler, Stephen V. Faraone, Eva Hiripi, et al.
PubMed Summary & key facts 2005 3,245 citations

The WHO Adult ADHD Self-Report Scale (ASRS) has 18 questions about recent ADHD symptoms, and a shorter six-question screener was tested against blind clinical diagnoses in 154 people from the US National Comorbidity Survey Replication. Each ASRS item was linked to the clinical rating, but agreement varied a lot across…

Attention Deficit Hyperactivity Disorder Functional Brain Connectivity Studies Neural and Behavioral Psychology Studies

Risks of all-cause and suicide mortality in mental disorders: a meta-review

Edward Chesney, Guy M. Goodwin, Seena Fazel
World Psychiatry Summary & key facts 2014 2,040 citations

This study reviewed systematic reviews to measure death risks in major mental disorders. The authors screened 407 reviews and found 20 that reported mortality risks for 20 different disorders, covering over 1.7 million patients and more than a quarter of a million deaths. Every disorder showed higher all-cause death rates…

Bipolar Disorder and Treatment Mental Health Treatment and Access Suicide and Self-Harm Studies

Epidemiology of anxiety disorders in the 21st century

Borwin Bandelow, Sophie Michaelis
Dialogues in Clinical Neuroscience Summary & key facts 2015 2,024 citations

Anxiety disorders are a group of conditions marked by persistent, excessive fear or worry and behaviors (like avoidance) that cause real trouble in daily life. They are the most common class of psychiatric disorder — large surveys report that up to 33.7% of people will have one in their lifetime…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Mental Health Treatment and Access

The health benefits of the great outdoors: A systematic review and meta-analysis of greenspace exposure and health outcomes

Caoimhe Twohig-Bennett, Andy Jones
PubMed Summary & key facts 2018 1,542 citations

This review combined 143 studies (103 observational and 40 intervention) that looked at about 100 health outcomes to see how contact with greenspace relates to health. Overall, more greenspace exposure was linked with lower stress markers, lower heart rate and some lower blood pressure, and with lower risks for outcomes…

Noise Effects and Management Urban Green Space and Health Urban Heat Island Mitigation

Loneliness in Older Persons

Carla Perissinotto, Irena Cenzer, Kenneth E. Covinsky
Archives of Internal Medicine Summary & key facts 2012 1,225 citations

This study followed 1,604 U.S. adults older than 60 for six years. It found that people who said they felt lonely (43% of the group) were more likely to have worse day-to-day function and were more likely to die. After the researchers adjusted for age, wealth, living situation, depression, and…

Aging and Gerontology Research Health and Wellbeing Research Health disparities and outcomes

Effectiveness of physical activity interventions for improving depression, anxiety and distress: an overview of systematic reviews

Ben Singh, Tim Olds, Rachel Curtis, Dorothea Dumuid, Rosa Virgara, Amanda Watson, et al.
PubMed Summary & key facts 2023 784 citations

This umbrella review pooled evidence from 97 systematic reviews (1,039 randomized trials, 128,119 participants) to examine whether physical activity affects symptoms of depression, anxiety and psychological distress in adults. Overall, physical activity produced medium-sized reductions in symptoms (median effect size for depression = -0.43, for anxiety = -0.42; distress effect…

Behavioral Health and Interventions Eating Disorders and Behaviors Physical Activity and Health

Review of the burden of eating disorders: mortality, disability, costs, quality of life, and family burden

Daphne van Hoeken, Hans W. Hoek
Current Opinion in Psychiatry Summary & key facts 2020 716 citations

This review found that eating disorders cause a large health and social burden. In 2017 eating disorders accounted for more than 3.3 million healthy years lost worldwide. Anorexia nervosa and bulimia nervosa show rising disability, higher death rates (especially after inpatient treatment for anorexia), lower quality of life, higher costs,…

Eating Disorders and Behaviors Obesity, Physical Activity, Diet Obsessive-Compulsive Spectrum Disorders

Trends in depression prevalence in the USA from 2005 to 2015: widening disparities in vulnerable groups

Andrea H. Weinberger, Misato Gbedemah, Adriana Maldonado, Denis Nash, Sandro Galea, Renée D. Goodwin
Psychological Medicine Summary & key facts 2017 704 citations

A U.S. study reported that depression became more common between 2005 and 2015. The rise was faster for young people than for older adults. The study also found growing gaps in depression rates for vulnerable groups. The authors say we do not yet know a single cause and that more…

Cardiac Health and Mental Health Health disparities and outcomes Mental Health Treatment and Access

Adult ADHD and comorbid disorders: clinical implications of a dimensional approach

Martin A. Katzman, Timothy S. Bilkey, Pratap Chokka, Angelo Fallu, Larry J. Klassen
BMC Psychiatry Summary & key facts 2017 648 citations

This review says adult ADHD affects about 2.5% of adults and often occurs with other mental health problems. Adults with ADHD commonly have trouble with attention, memory, planning, self-control, and emotions. The condition is often missed or undertreated, is linked with big personal and social problems, and the evidence on…

Attention Deficit Hyperactivity Disorder Functional Brain Connectivity Studies Neural and Behavioral Psychology Studies

Mentalization based treatment for borderline personality disorder

Anthony Bateman, Peter Fonagy
World Psychiatry Summary & key facts 2010 637 citations

Borderline personality disorder (BPD) is a serious mental illness marked by big problems with emotion control, impulsive acts, and unstable self-image and relationships. Many people with BPD hurt themselves or try suicide (recurrent suicidal behaviour in about 69–80% and suicide rates up to 10%). Mentalization-based treatment (MBT) was developed to…

Bipolar Disorder and Treatment Personality Disorders and Psychopathology Psychotherapy Techniques and Applications

Folic Acid Food Fortification—Its History, Effect, Concerns, and Future Directions

Krista S. Crider, Lynn B. Bailey, R. J. Berry
Nutrients Summary & key facts 2011 583 citations

Folic acid is a stable, synthetic form of the vitamin folate. Taking folic acid around the time of conception lowers the chance of neural tube birth defects (NTDs). Many countries have added folic acid to flour and other foods. These fortification programs have been linked with large drops in NTDs,…

Folate and B Vitamins Research Iron Metabolism and Disorders Phytase and its Applications
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