Frontier mental health research: psychedelics & drug studies

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6 papers

Artificial Intelligence Risk Management Framework (AI RMF 1.0)

Elham Tabassi
NIST Summary & key facts 2023 466 citations

The NIST AI Risk Management Framework (AI RMF 1.0) is a voluntary guide published in January 2023 to help organizations of all sizes manage the risks of AI and promote trustworthy, responsible AI. It sets out core trustworthiness goals (like safety, fairness, privacy, and reliability) and a practical structure of…

Artificial Intelligence in Healthcare and Education

Impact of anxiety on prefrontal cortex encoding of cognitive flexibility

Junchol Park, Bita Moghaddam
Neuroscience Summary & key facts 2016 221 citations

This review looks at studies in humans and animals that link anxiety and stress with poorer cognitive flexibility — the ability to change strategies when rules or goals change. It describes evidence that the prefrontal cortex (PFC) is central to flexible behavior, that anxiety or PFC disruptions are associated with…

Memory and Neural Mechanisms Neural and Behavioral Psychology Studies Stress Responses and Cortisol

Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting

Luisa Prochazkova, Dominique P. Lippelt, Lorenza S. Colzato, Martin Kuchař, Zsuzsika Sjoerds, Bernhard Hommel
Psychopharmacology Summary & key facts 2018 176 citations

In a natural, open-label study at a microdosing event, researchers tested people before and while they expected the effects of a psychedelic truffle microdose. They found better performance on a task that measures convergent thinking and on a task that measures divergent thinking. A short test of fluid intelligence did…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies

Psychological flexibility as a mechanism of change in psilocybin-assisted therapy for major depression: results from an exploratory placebo-controlled trial

Sloshower, Jordan, Zeifman, Richard J., Guss, Jeffrey, et al.
Nature Summary & key facts 2024 46 citations

This small, exploratory study gave people with moderate to severe major depressive disorder placebo first (19 people) and then a single dose of psilocybin (0.3 mg/kg) to 15 people four weeks later, with all dosing embedded in therapy based on Acceptance and Commitment Therapy (ACT). After the psilocybin session, measures…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies

Four Weeks of Hericium erinaceus Supplementation Does Not Impact Markers of Metabolic Flexibility or Cognition

Corey D. Grozier, Victor A Alves, Lauren G. Killen, Jeffrey D. Simpson, Eric K. O’Neal, Hunter S. Waldman

Researchers tested whether taking 10 g per day of Hericium erinaceus (Lion's Mane mushroom) for four weeks changes how the body uses fuel during exercise or affects thinking in a college-age group. In a single-blind, placebo-controlled trial, 24 participants ate muffins with either the mushroom or a placebo and completed…

Exercise and Physiological Responses Fungal Biology and Applications Muscle metabolism and nutrition

Technological folie à deux: Feedback Loops Between AI Chatbots and Mental Illness

Sebastian Dohnány, Zeb Kurth‐Nelson, Eleanor Spens, Lennart Luettgau, Ann Reid, Iason Gabriel, et al.
ArXiv.org Summary & key facts 2025 6 citations

This paper says that millions of people now use AI chatbots for emotional support. The authors note reports of harms — including suicide, violence, and delusional thinking — linked to people forming emotional relationships with chatbots. They argue that chatbot traits like strong agreeableness and fast adaptation can interact with…

AI in Service Interactions Digital Mental Health Interventions Mental Health via Writing
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