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Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Peroxisome Proliferator-Activated Receptors Gene

1 paper

Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity

Xavier Nadal, Carmen del Río, Salvatore Casano, Belén Palomares, Carlos Ferreiro‐Vera, Carmen Navarrete, et al.
PubMed Central (PMC) Summary & key facts 2017 124 citations

This study tested Δ9‑tetrahydrocannabinolic acid (Δ9‑THCA), the acidic form of THC, in lab cells and in mice. The researchers found that Δ9‑THCA activates the nuclear receptor PPARγ more strongly than neutral cannabinoids, increased mitochondrial mass in neuroblastoma cells, reduced cell damage caused by mutant huntingtin in cell models, and improved…

Cannabis and Cannabinoid Research Lipid metabolism and biosynthesis Peroxisome Proliferator-Activated Receptors
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