Frontier mental health research: psychedelics & drug studies

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15 papers

Epidemiology of anxiety disorders in the 21st century

Borwin Bandelow, Sophie Michaelis
Dialogues in Clinical Neuroscience Summary & key facts 2015 2,024 citations

Anxiety disorders are a group of conditions marked by persistent, excessive fear or worry and behaviors (like avoidance) that cause real trouble in daily life. They are the most common class of psychiatric disorder — large surveys report that up to 33.7% of people will have one in their lifetime…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Mental Health Treatment and Access

Cognitive-behavioral therapy for anxiety disorders: an update on the empirical evidence

Antonia N. Kaczkurkin, Edna B. Foa

This article reviews a large body of research on cognitive-behavioral therapy (CBT) for anxiety disorders. It focuses on two common CBT methods — exposure therapy and cognitive therapy — and concludes that CBT generally works for many anxiety problems. The authors also say it is hard to compare active CBT…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Mental Health Research Topics

Why do people with anxiety disorders become depressed? A prospective‐longitudinal community study

Hans‐Ulrich Wïttchen, Ronald C. Kessler, Hildegard Pfister, Michael Höfler, R. Lieb
Acta Psychiatrica Scandinavica Summary & key facts 2000 442 citations

In a community study of 3,021 adolescents and young adults followed for 4–5 years, researchers used structured interviews (DSM‑IV CIDI) and found that most anxiety disorders (except panic disorder) began before depression and were linked to a higher chance of later major depression. Rates of people having both anxiety and…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Maternal Mental Health During Pregnancy and Postpartum

Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options

Amir Garakani, James W. Murrough, Rafael C. Freire, Robyn P. Thom, Kaitlyn Larkin, Frank D. Buono, et al.
Frontiers in Psychiatry Summary & key facts 2020 395 citations

This review summarizes drug treatments for adult anxiety disorders (panic disorder, generalized anxiety disorder, social anxiety disorder, and specific phobias). It says well-known drugs such as SSRIs and SNRIs are commonly used and approved for some anxiety disorders. The authors found that research into truly new medications is limited, many…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Pharmacological Receptor Mechanisms and Effects Tryptophan and brain disorders

The prevalence and burden of subthreshold generalized anxiety disorder: a systematic review

Heidemarie Haller, Holger Cramer, Romy Lauche, Florian Gaß, Gustav Dobos
BMC Psychiatry Summary & key facts 2014 270 citations

The article describes “high functioning anxiety” as a way some people with anxiety symptoms talk about their experience, not as an official medical diagnosis. It says people can look successful and cope outwardly while having common anxiety symptoms, and that diagnosis can be hard because the symptom effects may be…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Maternal Mental Health During Pregnancy and Postpartum

Differential alterations of resting‐state functional connectivity in generalized anxiety disorder and panic disorder

HuiRu Cui, Jie Zhang, Yicen Liu, Qingwei Li, Hui Li, Lanlan Zhang, et al.
Human Brain Mapping Summary & key facts 2016 117 citations

Researchers compared whole-brain resting-state functional connectivity in 21 people with generalized anxiety disorder (GAD), 18 people with panic disorder (PD), and 22 matched healthy controls. They used a new measure called scaled correlation to look for differences across the brain. GAD showed stronger connections between the hippocampus/parahippocampus and the fusiform…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Functional Brain Connectivity Studies Neural dynamics and brain function

Cognitive-Behavioral Treatments for Anxiety and Stress-Related Disorders

Joshua Curtiss, Daniella Levine, Ilana Ander, Amanda W. Baker

This review says cognitive-behavioral therapy (CBT) is a well-researched, first-line treatment for anxiety and related disorders. CBT is structured and often manualized, usually delivered weekly for a limited period (about 12–16 weeks) and sometimes followed by booster sessions. Core CBT methods are cognitive techniques (like identifying thinking traps, cognitive restructuring,…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Digital Mental Health Interventions

Muscle tension in generalized anxiety disorder: Elevated muscle tonus or agitated movement?

Richard L. Hazlett, Daniel R. McLeod, Rudolf Hoehn‐Saric
Psychophysiology Summary & key facts 1994 76 citations

The study recorded electrical muscle activity (EMG) from the forehead (frontalis) and calf (gastrocnemius) in 18 women with generalized anxiety disorder (GAD) and 19 nonanxious women during baseline, a lab stressor, and recovery. The GAD group had higher average EMG levels, and during the stressor they showed a drop in…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Obsessive-Compulsive Spectrum Disorders Psychosomatic Disorders and Their Treatments

Psychotherapies for Generalized Anxiety Disorder in Adults: A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials

Davide Papola, Clara Miguel, Mariacristina Mazzaglia, Pamela Franco, Federico Tedeschi, Sara A Romero, et al.
PubMed Central (PMC) Summary & key facts 2023 63 citations

This review combined 65 randomized trials with 5,048 adults who had generalized anxiety disorder. The authors found that cognitive behavioral therapy (CBT) was linked with better short-term and long-term outcomes than treatment as usual. Third‑wave CBTs and relaxation therapy were linked with short-term benefits, but after removing studies judged to…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Mental Health Research Topics

Difficulty concentrating in generalized anxiety disorder: An evaluation of incremental utility and relationship to worry

Lauren S. Hallion, Shari A. Steinman, Susan Kusmierski
Journal of Anxiety Disorders Summary & key facts 2017 59 citations

This study looked at 175 adults with generalized anxiety disorder (GAD). Clinician-rated problems with concentrating were linked to higher GAD, anxiety, and depression severity even after other GAD symptoms were taken into account. The data also showed that difficulty concentrating statistically explained part of the link between a person’s tendency…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Mental Health Research Topics

Clinical Practice Guidelines for the Management of Generalised Anxiety Disorder (GAD) and Panic Disorder (PD)

Shiv Gautam, Akhilesh Jain, Manaswi Gautam, VihangN Vahia, Anita Gautam
Indian Journal of Psychiatry Summary & key facts 2017 49 citations

These Indian clinical practice guidelines describe what generalized anxiety disorder (GAD) and panic disorder (PD) look like, how to assess them, and which treatments are commonly used. They say GAD involves worry most days for weeks or months, lists common symptoms, and recommends both medicines and psychological treatments. The guidelines…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Psychosomatic Disorders and Their Treatments

Restlessness in Generalized Anxiety Disorder: Using Actigraphy to Measure Physiological Reactions to Threat

Anna R. Franklin, Danielle C. Mathersul, Adrian Raine, Ayelet Meron Ruscio
Behavior Therapy Summary & key facts 2020 20 citations

Researchers tested 102 adults with and without generalized anxiety disorder (GAD) to see if a wrist-and-ankle movement monitor (actigraphy) could measure restlessness during a lab threat task. People with GAD said they felt more restless than people without GAD. The actigraphy readings rose as the threat got closer, and people…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Mental Health Research Topics Psychosomatic Disorders and Their Treatments
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