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4 papers
This paper combined past studies (a meta-analysis) and a genetic test (Mendelian randomization) to look at blood testosterone and depression in women. The meta-analysis found that women with depression have significantly different serum testosterone levels than healthy women, with a clear result in premenopausal women and weaker (borderline) results in…
Researchers studied 1004 people with bipolar I disorder who had at least one depressive episode. They found that people who received antidepressant treatment were more likely to have a manic episode within eight weeks after their depression got better. A genetic marker (rs10262219) showed a strong signal in the first…
This paper reviews studies of genes and epigenetics in panic disorder. Family, twin, and adoption studies show panic disorder often runs in families. Researchers have found some candidate genes (for example NPY, ADORA2A, COMT, IKBKE), but panic disorder is not a single-gene disease. Large genome-wide studies did not find any…
The authors present a new association of two heterozygous TACR3 mutations (p.Arg230His and p.Trp275*) responsible for a clinical trait of normosmic congenital hypogonadotropic hypogonadism in a family.
