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13 papers
This paper is a meta-analysis of more than 300 studies in humans that looked at links between psychological stress and measures of the immune system. It found that very short, acute stressors (minutes) were tied to increases in some natural (innate) immune measures and decreases in some specific (adaptive) immune…
This study measured health-related quality of life (HRQoL) in Danish patients with ME/CFS using the EQ-5D-3L tool and found their scores were much lower than the general population and lower than 20 other conditions. The average (unadjusted) EQ-5D-3L score for the ME/CFS group was 0.47, while the population average was…
This 2021 review looked at research on the biology of burnout, which it defines as exhaustion from long or excessive workplace stress. The authors found evidence that burnout is linked with ongoing activation of the nervous system, problems in the body’s fast stress response (the sympathetic-adrenal-medullary axis), and changes in…
Researchers studied 85 married couples (170 people) to see if worries about close relationships (attachment anxiety) link to stress hormones and immune cells. People with higher attachment anxiety had higher saliva cortisol across three days and lower counts of several T-cell types in blood. The study is observational, mostly white…
This review looks at research on how cannabis and its active chemicals relate to psychosis. It says there are three patterns: short psychotic symptoms during intoxication, short psychosis that can last beyond intoxication (often resolving within a month in case reports), and persistent psychosis that is not clearly tied to…
This paper looks at whether 'mixed anxiety and depressive disorder' should be an official diagnosis. That label describes people who have both anxiety and depression symptoms that are real and limiting, but not strong enough to count as a full disorder on their own. The authors review studies that support…
This 2022 review looks at studies linking stress, inflammation, and changes in the amygdala to depression and anxiety. It says stress can trigger inflammation in the body and brain, that inflammation can change neurons and circuits in the amygdala, and that these changes are linked to depression- and anxiety-like signs…
Researchers had 13 healthy adults take Hericium erinaceus powder every day for seven days. They tested blood with routine blood and serum chemistry tests and checked gut bacteria using 16S rRNA gene sequencing. After the week, the gut bacterial community showed higher within-sample diversity and higher levels of several bacteria…
This 2025 narrative review explains that cortisol normally peaks in the early morning and falls to its lowest levels in the early night. Night-shift work often shifts or flattens that pattern, causing a blunted or delayed morning peak and a less steep decline through the day. The authors link this…
This Healthline article explains a body-based method called shaking therapy (also called TRE or neurogenic tremoring). It says some experts believe gentle shaking can help the nervous system release tension and calm stress. The article gives simple ways to try it, notes possible benefits people report, and also clearly says…
Polysaccharide-K (PSK, also called Krestin) is a mushroom extract widely used as an additive in cancer treatment in Asia, especially Japan. Studies over about 40 years report anti-tumor effects in laboratory experiments and in living organisms for several cancer types, but researchers say the exact ways PSK works are not…
