Frontier mental health research: psychedelics & drug studies

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17 papers

Cannabis, Cannabinoids, and Sleep: a Review of the Literature

Kimberly A. Babson, James Sottile, Danielle M. Morabito
PubMed Summary & key facts 2017 470 citations

This 2017 review of studies up to 2014 looked at how cannabis and related drugs affect sleep. The authors found early, mixed evidence: cannabidiol (CBD) showed possible benefit for insomnia and some sleep disorders, THC might make people fall asleep faster but could harm sleep quality over time, and some…

Cannabis and Cannabinoid Research Sleep and related disorders Sleep and Wakefulness Research

Core symptoms of major depressive disorder: relevance to diagnosis and treatment

Sidney H Kennedy
PubMed Central (PMC) Summary & key facts 2008 370 citations

Major depressive disorder (MDD) is defined without assuming a single cause and has two main symptoms: depressed mood and loss of interest or pleasure. The paper says we should also pay more attention to fatigue, sleep problems, anxiety, thinking (cognitive) problems, and sexual problems when diagnosing and judging treatment. Some…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Mental Health Research Topics Treatment of Major Depression

The effects of physical activity on cortisol and sleep: A systematic review and meta-analysis

Len De Nys, Kerry Anderson, Esther Frema Ofosu, Gemma C. Ryde, Jenni Connelly, Anna C. Whittaker
Psychoneuroendocrinology Summary & key facts 2022 227 citations

This review combined results from 10 intervention studies to see if physical activity programs change cortisol (a stress hormone) and sleep in adults. The pooled results found lower cortisol after activity programs and some improvement in sleep quality. The authors say the evidence is moderate for cortisol and low for…

Circadian rhythm and melatonin Physical Activity and Health Sleep and related disorders

On the nature of burnout–insomnia relationships: A prospective study of employed adults

Galit Armon, Arie Shirom, Itzhak Shapira, Samuel Melamed

This study followed 1,356 apparently healthy, employed adults over about 18 months to see how burnout and insomnia change together. Using standard questionnaires, the researchers found that higher burnout predicted new cases of insomnia and higher insomnia predicted new cases of burnout, even after adjusting for depression and other factors.…

Health, psychology, and well-being Sleep and related disorders Workplace Health and Well-being

Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake

Mayumi Nagano, Kuniyoshi Shimizu, Ryuichiro Kondo, Chickako Hayashi, Daigo SATO, Katsuyuki Kitagawa, et al.
Biomedical Research Summary & key facts 2010 117 citations

In a small, randomized, placebo-controlled trial, 30 women ate Hericium erinaceus (HE) cookies or placebo cookies for 4 weeks. After HE intake, overall depression scores (CES-D) and scores for vague or indefinite complaints (ICI) were significantly lower than before. Two specific ICI items, written as "insentive" and "palpitatio," were lower…

Fungal Biology and Applications Medicinal Plants and Bioactive Compounds Pharmacological Effects of Natural Compounds

Sleep disturbance, circadian preference and symptoms of adult attention deficit hyperactivity disorder (ADHD)

Bogdan Voinescu, Aurora Szentágotai, Daniel David
Journal of Neural Transmission Summary & key facts 2012 88 citations

The researchers surveyed more than 550 adults in Romania with self-report questionnaires to study links between ADHD symptoms, sleep problems, and morning/evening preference. They found that people with probable ADHD more often had insomnia-type sleep problems (over 50%), slept less, took longer to fall asleep, and woke up more at…

Attention Deficit Hyperactivity Disorder Sleep and related disorders Sleep and Wakefulness Research

Cannabis use and sleep: Expectations, outcomes, and the role of age

Evan A. Winiger, Leah N. Hitchcock, Angela D. Bryan, L. Cinnamon Bidwell
Addictive Behaviors Summary & key facts 2020 63 citations

This study looked at 152 moderate cannabis users (21–70 years old) to see what they expect cannabis will do for sleep and what their reported sleep was like. Users were more likely to expect cannabis to help sleep, but the study found few clear links between cannabis use and better…

Cannabis and Cannabinoid Research Sleep and related disorders Sleep and Wakefulness Research

Nightmare Disorder and Isolated Sleep Paralysis

Ambra Stefani, Birgit Högl
Neurotherapeutics Summary & key facts 2020 63 citations

Nightmare disorder and isolated sleep paralysis are REM-related sleep problems that can cause real distress. Nightmare disorder means repeated, very upsetting, well-remembered dreams that wake a person and hurt their mood, sleep, or daily life. Isolated sleep paralysis is a state where the body stays in REM sleep muscle paralysis…

Memory and Neural Mechanisms Sleep and related disorders Sleep and Wakefulness Research

Interventions for Sleep Disturbance in Bipolar Disorder

Allison G Harvey, Kate A Kaplan, Adriane Soehner
PubMed Central (PMC) Summary & key facts 2015 45 citations

This review explains that sleep problems are common in bipolar disorder and are tied to worse mood, more relapse, and more daily problems. The authors describe non-drug treatments for sleep, especially adapted cognitive behavioral therapy for insomnia (CBT-I), and note some evidence and limits for these approaches.

Bipolar Disorder and Treatment Sleep and related disorders Sleep and Wakefulness Research

The Effects of Cannabinoids on Sleep

Bhanu Prakash Kolla, Lisa Hayes, Chaun Cox, Lindy Eatwell, Mark Deyo-Svendsen, Meghna P. Mansukhani

This article reviews studies and a patient case about how cannabis and related compounds affect sleep. The authors found that the research is limited and often small or observational. Overall, cannabis products seem to have little or no clear benefit for sleep disorders and can cause sleep problems for some…

Cannabis and Cannabinoid Research Sleep and related disorders Sleep and Wakefulness Research

Use of Cannabidiol in the Management of Insomnia: A Systematic Review

Rylea Ranum, Mary O. Whipple, Ivana T. Croghan, Brent Bauer, Loren Toussaint, Ann Vincent

This review looked at 34 studies that tested cannabidiol (CBD) for sleep problems. Some studies used mostly CBD and others used CBD with similar amounts of THC. Many studies reported that at least some participants had better sleep, but very few studies focused only on people with insomnia and most…

Cannabis and Cannabinoid Research Sleep and related disorders Sleep and Wakefulness Research

Sleep and Alcohol Use Patterns During Federal Holidays and Daylight Saving Time Transitions in the United States

Heacock, Rachel M., Capodilupo, Emily R., Czeisler, Mark É., et al.
www.frontiersin.org Summary & key facts 2022 25 citations

This study used data from 24,250 U.S. users of the WHOOP wearable (74.5% male, mean age 37.6 years) collected from May 1, 2020 to May 1, 2021. Compared to typical days, most U.S. public holidays, holiday eves, and Daylight Saving Time transitions showed clear changes: people tended to sleep longer,…

Impact of Light on Environment and Health Sleep and related disorders Sleep and Work-Related Fatigue
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