Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

58 papers

Exercise: a behavioral intervention to enhance brain health and plasticity

Carl W. Cotman
Trends in Neurosciences Summary & key facts 2002 2,668 citations

This 2002 review looked at animal and human research on exercise and the brain. It reports that voluntary exercise in animals raises levels of brain-derived neurotrophic factor (BDNF) and other growth factors, spurs the birth of new neurons, changes gene activity in ways that support plasticity, and can improve learning…

Adipose Tissue and Metabolism Nerve injury and regeneration Neurogenesis and neuroplasticity mechanisms

Effects of mindfulness on psychological health: A review of empirical studies

Shian‐Ling Keng, Moria J. Smoski, Clive J. Robins
Clinical Psychology Review Summary & key facts 2011 2,599 citations

This 2011 review looked at many studies on mindfulness and mental health. It defines mindfulness as paying attention in the present with nonjudgmental acceptance and says this involves both focusing attention and an open, curious attitude. The authors examined three kinds of research—correlational studies, intervention trials, and lab experiments—and concluded…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Mindfulness and Compassion Interventions Religion, Spirituality, and Psychology

Self-Compassion: Theory, Method, Research, and Intervention

Kristin D. Neff
PubMed Summary & key facts 2023 721 citations

This review defines self-compassion as being supportive toward yourself during suffering and presents a six-part model (more self-kindness and common humanity and mindfulness; less self-judgment, isolation, and overidentification). It summarizes a growing set of empirical studies that suggest self-compassion helps people handle distressing thoughts and emotions and is linked to…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Mindfulness and Compassion Interventions

Mindfulness-Based Interventions for Anxiety and Depression

Stefan G Hofmann, Angelina F Gómez
PubMed Central (PMC) Summary & key facts 2017 706 citations

Mindfulness-based interventions (MBIs), especially Mindfulness-Based Stress Reduction (MBSR) and Mindfulness-Based Cognitive Therapy (MBCT), teach people to pay nonjudgmental attention to the present moment. Reviews and randomized trials show MBIs can reduce anxiety and depression symptom severity across many groups, often doing better than non-evidence treatments or active controls and performing…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Mindfulness and Compassion Interventions

A Randomized Controlled Effectiveness Trial of Acceptance and Commitment Therapy and Cognitive Therapy for Anxiety and Depression

Evan M. Forman, James D. Herbert, Ethan Moitra, Peter D. Yeomans, Pamela A. Geller
Behavior Modification Summary & key facts 2007 682 citations

The source explains what Acceptance and Commitment Therapy (ACT) is and reports research comparing ACT with cognitive therapy (CT). In a randomized trial of 101 outpatients with moderate to severe anxiety or depression, people assigned to ACT or to CT showed large, similar improvements in depression, anxiety, daily functioning, quality…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Complementary and Alternative Medicine Studies Mindfulness and Compassion Interventions

The effects of physical activity on cortisol and sleep: A systematic review and meta-analysis

Len De Nys, Kerry Anderson, Esther Frema Ofosu, Gemma C. Ryde, Jenni Connelly, Anna C. Whittaker
Psychoneuroendocrinology Summary & key facts 2022 227 citations

This review combined results from 10 intervention studies to see if physical activity programs change cortisol (a stress hormone) and sleep in adults. The pooled results found lower cortisol after activity programs and some improvement in sleep quality. The authors say the evidence is moderate for cortisol and low for…

Circadian rhythm and melatonin Physical Activity and Health Sleep and related disorders

Effects of voluntary slow breathing on heart rate and heart rate variability: A systematic review and a meta-analysis

Sylvain Laborde, Mark S. Allen, Uirassu Borges, Fabrice Dosseville, Thomas J. Hosang, Maša Iskra, et al.
PubMed Summary & key facts 2022 205 citations

This 2022 systematic review and meta-analysis pooled data from 223 studies to see if voluntary slow breathing (VSB) changes heart rate variability that reflects parasympathetic (vagal) control of the heart. The authors found that VSB increased vagally-mediated heart rate variability during breathing sessions, right after a single session, and after…

Cardiac Health and Mental Health Cardiovascular and exercise physiology Heart Rate Variability and Autonomic Control

Meditation and yoga for posttraumatic stress disorder: A meta-analytic review of randomized controlled trials

Autumn M. Gallegos, Hugh F. Crean, Wilfred R. Pigeon, Kathi L. Heffner
Clinical Psychology Review Summary & key facts 2017 178 citations

This paper pooled results from 19 randomized trials with 1,173 adults to see if meditation and yoga change PTSD symptoms. Overall, these mind–body practices were linked to a small-to-medium reduction in PTSD symptoms (effect size = −0.39). The authors found no big differences by type of practice, who was studied,…

Mindfulness and Compassion Interventions Posttraumatic Stress Disorder Research Resilience and Mental Health

Breathing‐Based Meditation Decreases Posttraumatic Stress Disorder Symptoms in U.S. Military Veterans: A Randomized Controlled Longitudinal Study

Emma Seppälä, Jack B. Nitschke, Dana Tudorascu, Andrea S Hayes, Michael R. Goldstein, Dong T. H. Nguyen, et al.
Journal of Traumatic Stress Summary & key facts 2014 177 citations

This randomized study tested a breathing-based meditation (Sudarshan Kriya yoga) in 21 male U.S. veterans of the Iraq or Afghanistan wars. Participants were randomly assigned to the meditation group (n = 11) or a waitlist control (n = 10). The meditation group showed reductions in self-reported PTSD symptoms, anxiety, and…

Mindfulness and Compassion Interventions Posttraumatic Stress Disorder Research Stress Responses and Cortisol

Review of Smartphone Applications for the Treatment of Eating Disorders

Adrienne S. Juarascio, Stephanie M. Manasse, Stephanie P. Goldstein, Evan M. Forman, Meghan L. Butryn
European Eating Disorders Review Summary & key facts 2014 148 citations

This review looked at smartphone apps made for treating eating disorders. The authors found that research on whether these apps work is scarce. They also found that most existing apps include few proven treatment methods and do not use the special abilities of smartphones (like real-time interaction and sensors). The…

Eating Disorders and Behaviors Impact of Technology on Adolescents Mobile Health and mHealth Applications

Cognitive behavior therapy for chronic subjective dizziness: a randomized, controlled trial

Sarah Edelman, Alison Mahoney, Phillip D. Cremer

This randomized, controlled trial tested a brief cognitive behavioral therapy (CBT) program for 41 patients with chronic subjective dizziness. The program was three weekly sessions led by a clinical psychologist and used psychoeducation, behavioral experiments, exposure, and attention refocusing. After treatment, patients showed large, significant reductions in dizziness-related disability, physical…

Glaucoma and retinal disorders Hearing, Cochlea, Tinnitus, Genetics Vestibular and auditory disorders

Psychedelic-Assisted Psychotherapy—A Systematic Review of Associated Psychological Interventions

Cavarra, Mauro, Falzone, Alessandra, Ramaekers, Johannes G., et al.
www.frontiersin.org Summary & key facts 2022 122 citations

This systematic review looked at clinical studies that paired psychedelics with a structured psychotherapy. It found that psychedelic-assisted psychotherapy can give promising results across many clinical conditions when given to carefully screened people in controlled settings, but some patients relapse or do not respond. The review highlights that individual and…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies
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