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Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Treatment of Major Depression Magnetic resonance imaging

1 paper

Rapid neuroplasticity changes and response to intravenous ketamine: a randomized controlled trial in treatment-resistant depression

Jared M. Kopelman, Timothy A. Keller, Benjamin Panny, Angela Griffo, Michelle Degutis, Crystal Spotts, et al.
Translational Psychiatry Summary & key facts 2023 52 citations

In a randomized trial, 98 adults with treatment-resistant depression had brain scans before and 24 hours after a single intravenous infusion of ketamine (0.5 mg/kg) or saline. The researchers measured mean diffusivity (DTI-MD), an MRI-based, indirect marker of microstructural brain change that tends to fall when new synapses or tissue…

Advanced MRI Techniques and Applications Functional Brain Connectivity Studies Treatment of Major Depression
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