Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

4 papers

The effects of physical activity on cortisol and sleep: A systematic review and meta-analysis

Len De Nys, Kerry Anderson, Esther Frema Ofosu, Gemma C. Ryde, Jenni Connelly, Anna C. Whittaker
Psychoneuroendocrinology Summary & key facts 2022 227 citations

This review combined results from 10 intervention studies to see if physical activity programs change cortisol (a stress hormone) and sleep in adults. The pooled results found lower cortisol after activity programs and some improvement in sleep quality. The authors say the evidence is moderate for cortisol and low for…

Circadian rhythm and melatonin Physical Activity and Health Sleep and related disorders

Neurobiological Changes Induced by Mindfulness and Meditation: A Systematic Review

Andrea Calderone, Dèsiréè Latella, Federica Impellizzeri, Paolo De Pasquale, Fausto Famà, Angelo Quartarone, et al.
Biomedicines Summary & key facts 2024 49 citations

This systematic review of research up to 2024 found that meditation and mindfulness are linked to measurable brain changes and to better emotional regulation, cognition, and stress resilience. Many studies report thicker cortex in certain areas, lower amygdala reactivity, changes in brain connectivity and neurotransmitters, and improvements in anxiety, depression,…

Mindfulness and Compassion Interventions Music Therapy and Health Sleep and related disorders

Use of Cannabidiol in the Management of Insomnia: A Systematic Review

Rylea Ranum, Mary O. Whipple, Ivana T. Croghan, Brent Bauer, Loren Toussaint, Ann Vincent

This review looked at 34 studies that tested cannabidiol (CBD) for sleep problems. Some studies used mostly CBD and others used CBD with similar amounts of THC. Many studies reported that at least some participants had better sleep, but very few studies focused only on people with insomnia and most…

Cannabis and Cannabinoid Research Sleep and related disorders Sleep and Wakefulness Research

Medicinal cannabis in the management of anxiety disorders: A systematic review

L. Roberts, Elizabeth Sorial, Charley Budgeon, Kenneth Lee, David B. Preen, Craig Cumming
Psychiatry Research Summary & key facts 2025 1 citation

The authors reviewed 57 studies of medicinal cannabis for adults with anxiety disorders. Many studies—including over 90% that looked at CBD or THC—reported reduced anxiety symptoms, but the overall study quality was low (mean bias score 62.9/100) and long-term benefits and effects on quality of life are unclear. The review…

Cannabis and Cannabinoid Research Sleep and related disorders Sleep and Wakefulness Research
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