Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.
2 papers
Researchers found that the main kratom alkaloid, mitragynine, is turned by liver enzymes into a much more active compound called 7-hydroxymitragynine (7‑OH). In lab tests and in mice, 7‑OH acts more strongly at the mu-opioid receptor and reaches brain levels that can explain most or all of the pain relief…
This review explains how the main cannabis chemicals, especially THC and CBD, act in the body and how the body absorbs and breaks them down. THC and CBD bind to cannabinoid receptors (CB1 and CB2) in the brain and other organs. Inhaling THC delivers it to blood and brain fast…
