Frontier mental health research: psychedelics & drug studies

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2 papers

Hericenones and erinacines: stimulators of nerve growth factor (NGF) biosynthesis inHericium erinaceus

Bingji Ma, Jinwen Shen, Hai‐You Yu, Yuan Ruan, Tingting Wu, Xu Zhao

This review surveys the chemical and biological literature dealing with the isolation, structural elucidation and bioactivity of hericenones and erinacines from the fruiting body and mycelium of Hericium erinaceus, concentrating on work that has appeared in the literature up to December 2009.

Fungal Biology and Applications Medicinal Plants and Bioactive Compounds Phytochemistry and Biological Activities

Hericerin derivatives activates a pan‐neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory

Ramón Martínez‐Mármol, YeJin Chai, Jacinta N. Conroy, Zahra Khan, Seong‐Min Hong, Seon Beom Kim, et al.
Journal of Neurochemistry Summary & key facts 2023 36 citations

Researchers isolated two compounds from the medicinal mushroom Hericium erinaceus—N-de phenylethyl isohericerin (NDPIH) and hericene A. In lab cultures, these compounds caused strong axon growth and more branching in hippocampal neurons even without serum. Tests showed they activate ERK1/2 signaling and do not act only through the TrkB (BDNF) receptor.…

Fungal Biology and Applications Nerve injury and regeneration Pain Mechanisms and Treatments
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