Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

2 papers

Vagus nerve stimulation in treatment-resistant depression: A one-year, randomized, sham-controlled trial

Charles R. Conway, Scott T. Aaronson, Harold A. Sackeïm, Mark S. George, John Zajecka, Mark Bunker, et al.
Brain stimulation Summary & key facts 2024 23 citations

Researchers ran a one-year study of vagus nerve stimulation (VNS) in about 500 adults whose depression had not improved with many previous treatments. People were randomly assigned to get real VNS or a sham (no real stimulation), and neither they nor the main study staff knew which they had. The…

Heart Rate Variability and Autonomic Control Neurological disorders and treatments Vagus Nerve Stimulation Research

VNS Improves 5-Year Outcomes in Treatment-Resistant Depression

Nick Zagorski
Psychiatric News Summary & key facts 2017 0 citations

In a large, naturalistic five-year study, people with treatment-resistant depression who received an implanted vagus nerve stimulation (VNS) device plus their usual care had higher rates of symptom improvement and remission than similar patients who received usual care alone. The study followed 795 patients (494 with VNS, 301 usual care)…

Vagus Nerve Stimulation Research
Summaries and links are for general information and education only. They are not a substitute for reading the original publication or for professional medical, legal, or other advice. Always refer to the linked source for the full study.