Frontier mental health research: psychedelics & drug studies

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4 papers

Critical Period Plasticity as a Framework for Psychedelic-Assisted Psychotherapy

Lepow, Lauren, Morishita, Hirofumi, Yehuda, Rachel
www.frontiersin.org Summary & key facts 2021 68 citations

This paper suggests a new way to study how psychedelic-assisted psychotherapy (PAP) might work. The authors propose that psychedelics could put the adult brain into a state similar to developmental "critical periods," times when the brain is highly sensitive to experience. They recommend using a well-studied visual system model (ocular…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies

Serotonergic Psychedelics in Neural Plasticity

Kacper Łukasiewicz, Jacob J. Baker, Yi Zuo, Ju Lu

This review explains that classical serotonergic psychedelics — drugs like psilocybin, DMT (in ayahuasca), LSD, and ibogaine — can change brain cells and connections in lab and animal studies. These drugs have been shown to help neurons grow new branches and form more synapses, which are the contact points where…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies Ayahuasca Ibogaine

Bedside to bench: the outlook for psychedelic research

Victor P. Acero, Emily S. Cribas, Kevin D. Browne, Olivia Rivellini, Justin C. Burrell, John C. O’Donnell, et al.
Frontiers in Pharmacology Summary & key facts 2023 18 citations

This paper is a review of recent research on psychedelic drugs. The authors say some clinical trials show these drugs can help people with post-traumatic stress disorder, substance abuse problems, and depression that has not improved with other treatments. But scientists do not yet understand all the biological ways these…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies

Mushrooms, Microdosing, and Mental Illness: The Effect of Psilocybin on Neurotransmitters, Neuroinflammation, and Neuroplasticity

Daniel A Kinderlehrer

This review looks at how psilocybin mushrooms and their active ingredient psilocin might affect the brain and mental health. The authors say that brain inflammation seems to play a role in many cases of depression and anxiety. Lab and clinical studies show that psilocin can lower brain inflammation, boost the…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies Psilocybin
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