Frontier mental health research: psychedelics & drug studies

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2 papers

Substance abuse, memory, and post-traumatic stress disorder

Megan E. Tipps, Jonathan D. Raybuck, K. Matthew Lattal

This review looks at how three common drugs of abuse—nicotine, cocaine, and alcohol—change learning and memory and how those changes connect with stress and post-traumatic stress disorder (PTSD). The authors describe how these drugs can either help or hurt memory depending on dose, how long they are used, and whether…

Memory and Neural Mechanisms Neuroscience and Neuropharmacology Research Nicotinic Acetylcholine Receptors Study

What We Have Gained from Ibogaine: α3β4 Nicotinic Acetylcholine Receptor Inhibitors as Treatments for Substance Use Disorders

Carolyn J. Straub, Lisa E. Rusali, Kyle M. Kremiller, Andrew P. Riley
Journal of Medicinal Chemistry Summary & key facts 2022 16 citations

Researchers reviewing ibogaine and its chemical relatives say these drugs point to a new way to treat substance use disorders by blocking a brain receptor called α3β4 nicotinic acetylcholine receptor (nAChR). Animal studies found ibogaine and some derivatives reduced self-use of drugs like morphine, cocaine, alcohol, and nicotine. But ibogaine…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Nicotinic Acetylcholine Receptors Study
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