Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

58 papers

Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic

COVID-19 Mental Disorders Collaborators
PubMed Central (PMC) Summary & key facts 2021 5,135 citations

This study reviewed surveys and used global models to measure how the COVID-19 pandemic changed rates of major depressive disorder and anxiety disorders in 2020. It found that places with higher COVID-19 infection rates and bigger drops in movement had larger increases in these disorders. The authors estimate about 53.2…

COVID-19 and Mental Health Health disparities and outcomes Long-Term Effects of COVID-19

The Efficacy of Cognitive Behavioral Therapy: A Review of Meta-analyses

Stefan G. Hofmann, Anu Asnaani, Imke J. J. Vonk, Alice T. Sawyer, Angela Fang
Cognitive Therapy and Research Summary & key facts 2012 3,230 citations

This 2012 paper reviewed meta-analyses on cognitive behavioral therapy (CBT). The authors found 269 meta-analytic studies and examined a representative sample of 106 reviews across many problems. They reported the strongest support for CBT for anxiety disorders, somatoform disorders, bulimia, anger control problems, and general stress. The paper concluded the…

Child and Adolescent Psychosocial and Emotional Development Personality Disorders and Psychopathology Psychotherapy Techniques and Applications

The health benefits of the great outdoors: A systematic review and meta-analysis of greenspace exposure and health outcomes

Caoimhe Twohig-Bennett, Andy Jones
PubMed Summary & key facts 2018 1,542 citations

This review combined 143 studies (103 observational and 40 intervention) that looked at about 100 health outcomes to see how contact with greenspace relates to health. Overall, more greenspace exposure was linked with lower stress markers, lower heart rate and some lower blood pressure, and with lower risks for outcomes…

Noise Effects and Management Urban Green Space and Health Urban Heat Island Mitigation

Loneliness in Older Persons

Carla Perissinotto, Irena Cenzer, Kenneth E. Covinsky
Archives of Internal Medicine Summary & key facts 2012 1,225 citations

This study followed 1,604 U.S. adults older than 60 for six years. It found that people who said they felt lonely (43% of the group) were more likely to have worse day-to-day function and were more likely to die. After the researchers adjusted for age, wealth, living situation, depression, and…

Aging and Gerontology Research Health and Wellbeing Research Health disparities and outcomes

Review of the burden of eating disorders: mortality, disability, costs, quality of life, and family burden

Daphne van Hoeken, Hans W. Hoek
Current Opinion in Psychiatry Summary & key facts 2020 716 citations

This review found that eating disorders cause a large health and social burden. In 2017 eating disorders accounted for more than 3.3 million healthy years lost worldwide. Anorexia nervosa and bulimia nervosa show rising disability, higher death rates (especially after inpatient treatment for anorexia), lower quality of life, higher costs,…

Eating Disorders and Behaviors Obesity, Physical Activity, Diet Obsessive-Compulsive Spectrum Disorders

Trends in depression prevalence in the USA from 2005 to 2015: widening disparities in vulnerable groups

Andrea H. Weinberger, Misato Gbedemah, Adriana Maldonado, Denis Nash, Sandro Galea, Renée D. Goodwin
Psychological Medicine Summary & key facts 2017 704 citations

A U.S. study reported that depression became more common between 2005 and 2015. The rise was faster for young people than for older adults. The study also found growing gaps in depression rates for vulnerable groups. The authors say we do not yet know a single cause and that more…

Cardiac Health and Mental Health Health disparities and outcomes Mental Health Treatment and Access

Making health habitual: the psychology of ‘habit-formation’ and general practice

Benjamin Gardner, Phillippa Lally, Jane Wardle

This paper explains how habits form and how doctors might use habit-based advice in routine care. It says repeating a simple action in the same context can make that action automatic, so it needs less attention and may last after motivation falls. The authors report studies (for example, an average…

Behavioral Health and Interventions Health Policy Implementation Science Mental Health and Psychiatry

Chronic Pain Among Adults — United States, 2019–2021

S. Michaela Rikard, Andrea E. Strahan, Kristine M Schmit, Gery P. Guy

This CDC analysis used the 2019–2021 National Health Interview Survey to estimate how common chronic pain is among U.S. adults. In 2021, about 20.9% of adults (51.6 million people) reported pain on most days or every day for the past three months. About 6.9% (17.1 million people) had high-impact chronic…

Musculoskeletal pain and rehabilitation Opioid Use Disorder Treatment Pain Management and Opioid Use

The Health-Related Quality of Life for Patients with Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS)

Michael Falk Hvidberg, Louise Brinth, Anne Vingaard Olesen, Karin Dam Petersen, Lars Holger Ehlers
PLoS ONE Summary & key facts 2015 212 citations

This study measured health-related quality of life (HRQoL) in Danish patients with ME/CFS using the EQ-5D-3L tool and found their scores were much lower than the general population and lower than 20 other conditions. The average (unadjusted) EQ-5D-3L score for the ME/CFS group was 0.47, while the population average was…

Fibromyalgia and Chronic Fatigue Syndrome Research Resilience and Mental Health

Mental Health Prevention and Promotion—A Narrative Review

Vijender Singh, Akash Kumar, Snehil Gupta
Frontiers in Psychiatry Summary & key facts 2022 211 citations

This review summarizes research on promoting mental wellbeing and preventing mental illness. It says many prevention and promotion programs work, including newer digital and community-based approaches, but most strong evidence comes from high-income countries. The review notes big gaps in real-world use, especially in low- and middle-income countries, and calls…

Digital Mental Health Interventions Health disparities and outcomes Mental Health Treatment and Access

Treatment of post-partum depression: a review of clinical, psychological and pharmacological options

Kristin Leight, Elizabeth Fitelson, Sarah Kim, Allison S. Baker

Postpartum depression (PPD) is a common problem after childbirth. Most studies find rates around 10%–15% in high-income countries, and rates can be much higher in poorer settings. Untreated PPD is linked with problems in mother–baby bonding and with worse child development. Screening in routine obstetric, pediatric, or primary care visits…

Breastfeeding Practices and Influences Child and Adolescent Psychosocial and Emotional Development Maternal Mental Health During Pregnancy and Postpartum

Major depressive disorder: Validated treatments and future challenges

Rabie Karrouri, Zakaria HAMMANI, Roukaya Benjelloun, Yassine Otheman
World Journal of Clinical Cases Summary & key facts 2021 155 citations

Depression is a prevalent psychiatric disorder that often leads to poor quality of life and impaired functioning. Treatment during the acute phase of a major depressive episode aims to help the patient reach a remission state and eventually return to their baseline level of functioning. Pharmacotherapy, especially selective serotonin reuptake…

Electroconvulsive Therapy Studies Transcranial Magnetic Stimulation Studies Treatment of Major Depression
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