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2 papers
Researchers found that the main kratom alkaloid, mitragynine, is turned by liver enzymes into a much more active compound called 7-hydroxymitragynine (7‑OH). In lab tests and in mice, 7‑OH acts more strongly at the mu-opioid receptor and reaches brain levels that can explain most or all of the pain relief…
Researchers made new versions of the psychedelic drug ibogaine, called oxa-iboga compounds, by changing part of the chemical structure. In lab tests on human heart cells these new compounds did not show the heart-rhythm risk that ibogaine can cause. In tests with male rats, a single dose or a short…
