Frontier mental health research: psychedelics & drug studies

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24 papers

Muscle fatigue: what, why and how it influences muscle function

Roger M. Enoka, Jacques Duchateau
The Journal of Physiology Summary & key facts 2007 1,374 citations

This review explains that muscle fatigue can come from many different causes and that there is no single global cause. Fatigue is usually measured as a drop in the maximum force or power a muscle can make, but people can still do less-demanding tasks after that drop begins. Which processes…

Motor Control and Adaptation Muscle activation and electromyography studies Sports Performance and Training

On orthorexia nervosa: A review of the literature and proposed diagnostic criteria

Thomas M. Dunn, Steven Bratman
Eating Behaviors Summary & key facts 2015 596 citations

Orthorexia describes an extreme fixation on “healthy” eating that can harm a person’s health and life. The term was coined in 1997, but orthorexia is not an official diagnosis in the DSM-5‑TR, so how common it is and whether it is its own disorder or part of anorexia or OCD…

Child Nutrition and Feeding Issues Eating Disorders and Behaviors Obsessive-Compulsive Spectrum Disorders

The Effects of Tai Chi on Depression, Anxiety, and Psychological Well-Being: A Systematic Review and Meta-Analysis

Fang Wang, Eun‐Kyoung Othelia Lee, Taixiang Wu, Herbert Benson, Gregory L. Fricchione, Weidong Wang, et al.

This review collected studies of tai chi up to May 31, 2013 and found that many trials reported benefits for mood and psychological well-being. The authors included 37 randomized controlled trials and 5 quasi-experimental studies from English and Chinese databases. A small pooled analysis of three randomized trials that measured…

Art Therapy and Mental Health Balance, Gait, and Falls Prevention Physical Activity and Health

Cingulate dynamics track depression recovery with deep brain stimulation

Sankaraleengam Alagapan, Ki Sueng Choi, Stephen Heisig, Patricio Riva‐Posse, Andrea Crowell, Vineet Tiruvadi, et al.
Nature Summary & key facts 2023 233 citations

Researchers tested deep brain stimulation (DBS) in a small group of people whose depression did not get better with usual treatments. They used an implanted device that both delivered stimulation to the subcallosal cingulate (a brain area linked to mood) and recorded brain electrical signals. Around 9 out of 10…

Functional Brain Connectivity Studies Neurological disorders and treatments Transcranial Magnetic Stimulation Studies

Effects of voluntary slow breathing on heart rate and heart rate variability: A systematic review and a meta-analysis

Sylvain Laborde, Mark S. Allen, Uirassu Borges, Fabrice Dosseville, Thomas J. Hosang, Maša Iskra, et al.
PubMed Summary & key facts 2022 205 citations

This 2022 systematic review and meta-analysis pooled data from 223 studies to see if voluntary slow breathing (VSB) changes heart rate variability that reflects parasympathetic (vagal) control of the heart. The authors found that VSB increased vagally-mediated heart rate variability during breathing sessions, right after a single session, and after…

Cardiac Health and Mental Health Cardiovascular and exercise physiology Heart Rate Variability and Autonomic Control

Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome

Anthony J. Ocon
Frontiers in Physiology Summary & key facts 2013 151 citations

Chronic Fatigue Syndrome (CFS) is defined as more than 6 months of new, disabling physical and mental tiredness that is not relieved by rest. Up to about 85% of people with CFS report cognitive problems called “brain fog,” described as slow thinking, trouble focusing, confusion, forgetfulness, or a hazy mind.…

Fibromyalgia and Chronic Fatigue Syndrome Research Musculoskeletal pain and rehabilitation Olfactory and Sensory Function Studies

Cannabis analgesia in chronic neuropathic pain is associated with altered brain connectivity

Libat Weizman, Lior Dayan, Silviu Brill, Hadas Nahman‐Averbuch, Talma Hendler, Giris Jacob, et al.
Neurology Summary & key facts 2018 117 citations

In a small randomized, double-blind crossover study of 15 men with chronic radicular lower‑limb neuropathic pain, a single sublingual dose of THC (about 15.4 mg on average) reduced pain more than placebo. The amount of pain relief was linked to changes on resting‑state fMRI: reduced connectivity between emotional/cognitive brain areas…

Cannabis and Cannabinoid Research Pain Mechanisms and Treatments Psychedelics and Drug Studies Cannabis

Muscle tension in generalized anxiety disorder: Elevated muscle tonus or agitated movement?

Richard L. Hazlett, Daniel R. McLeod, Rudolf Hoehn‐Saric
Psychophysiology Summary & key facts 1994 76 citations

The study recorded electrical muscle activity (EMG) from the forehead (frontalis) and calf (gastrocnemius) in 18 women with generalized anxiety disorder (GAD) and 19 nonanxious women during baseline, a lab stressor, and recovery. The GAD group had higher average EMG levels, and during the stressor they showed a drop in…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Obsessive-Compulsive Spectrum Disorders Psychosomatic Disorders and Their Treatments

The impact of exercise on depression: how moving makes your brain and body feel better

Md Najmul Hossain, Jaeeun Lee, Hongseok Choi, Yi-Sub Kwak, Jongnam Kim
www.e-pan.org Summary & key facts 2024 75 citations

This review of research up to October 2023 explains many ways exercise may help people with depression. The authors describe biological changes (for example, more endorphins, less inflammation, and higher levels of brain-supporting molecules like BDNF), plus psychological and behavioral benefits (better sleep, less rumination, more self‑esteem and social contact).…

Psychological Well-being and Life Satisfaction Sleep and related disorders Tryptophan and brain disorders

The Effectiveness of the Feldenkrais Method: A Systematic Review of the Evidence

Susan Hillier, Anthea Worley

This systematic review looked at 20 randomized trials of the Feldenkrais Method (FM). Pooled results from 7 trials showed small but measurable balance improvements in older adults (for example, timed up and go was 1.14 seconds faster and functional reach improved by 6.08 cm). The studies and outcomes were very…

Balance, Gait, and Falls Prevention Foot and Ankle Surgery Musculoskeletal pain and rehabilitation

Pranayamas and their neurophysiological effects

Stephany Campanelli, AdrianoBretanha Lopes Tort, Bruno Lobão‐Soares
International Journal of Yoga Summary & key facts 2020 37 citations

This 2020 review looked at English studies on yogic breathing (pranayamas) published from 2008 to 2018. The authors screened 1,588 articles and analyzed 14 that met their criteria. Those 14 papers generally reported effects of pranayama on emotional states and on thinking or cognitive performance. The review also said the…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Heart Rate Variability and Autonomic Control Mindfulness and Compassion Interventions

Differential Experimental Effects of a Short Bout of Walking, Meditation, or Combination of Walking and Meditation on State Anxiety Among Young Adults

Meghan K. Edwards, Simon Rosenbaum, Paul D. Loprinzi

This randomized trial tested whether a single short bout of walking, meditation, or a combination changed short-term anxiety in young adults. One hundred ten university students (mean age 21.4 years) were randomly assigned to 10 minutes of walking, 10 minutes of meditation, walking then meditation, meditation then walking, or sitting.…

Mindfulness and Compassion Interventions Sleep and related disorders Urban Green Space and Health
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