Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

60 papers

Effects of physical exercise on anxiety, depression, and sensitivity to stress

Peter Salmon
Clinical Psychology Review Summary & key facts 2001 1,332 citations

This 2001 review looked at studies on exercise, anxiety, depression, and stress. It found that short-term emotional effects of exercise are mixed, but many cross-sectional and longitudinal studies report that regular aerobic exercise training reduces anxiety and depression symptoms and may protect against the harmful effects of stress. The clearest…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Eating Disorders and Behaviors Mental Health Research Topics

Loneliness in Older Persons

Carla Perissinotto, Irena Cenzer, Kenneth E. Covinsky
Archives of Internal Medicine Summary & key facts 2012 1,225 citations

This study followed 1,604 U.S. adults older than 60 for six years. It found that people who said they felt lonely (43% of the group) were more likely to have worse day-to-day function and were more likely to die. After the researchers adjusted for age, wealth, living situation, depression, and…

Aging and Gerontology Research Health and Wellbeing Research Health disparities and outcomes

A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial)

Jacka, Felice N., O’Neil, Adrienne, Opie, Rachelle, et al.
SpringerLink Summary & key facts 2017 1,000 citations

This 12-week randomised trial tested a structured dietary program (a modified Mediterranean-style diet) against a social-support control in adults with moderate to severe major depression. Sixty-seven people were randomised (33 to diet, 34 to control). The diet group showed larger drops in depressive symptoms on the MADRS scale at 12…

Diet and metabolism studies Eating Disorders and Behaviors Nutritional Studies and Diet

Effectiveness of physical activity interventions for improving depression, anxiety and distress: an overview of systematic reviews

Ben Singh, Tim Olds, Rachel Curtis, Dorothea Dumuid, Rosa Virgara, Amanda Watson, et al.
PubMed Summary & key facts 2023 784 citations

This umbrella review pooled evidence from 97 systematic reviews (1,039 randomized trials, 128,119 participants) to examine whether physical activity affects symptoms of depression, anxiety and psychological distress in adults. Overall, physical activity produced medium-sized reductions in symptoms (median effect size for depression = -0.43, for anxiety = -0.42; distress effect…

Behavioral Health and Interventions Eating Disorders and Behaviors Physical Activity and Health

Chronic Pain Among Adults — United States, 2019–2021

S. Michaela Rikard, Andrea E. Strahan, Kristine M Schmit, Gery P. Guy

This CDC analysis used the 2019–2021 National Health Interview Survey to estimate how common chronic pain is among U.S. adults. In 2021, about 20.9% of adults (51.6 million people) reported pain on most days or every day for the past three months. About 6.9% (17.1 million people) had high-impact chronic…

Musculoskeletal pain and rehabilitation Opioid Use Disorder Treatment Pain Management and Opioid Use

The Effects of Tai Chi on Depression, Anxiety, and Psychological Well-Being: A Systematic Review and Meta-Analysis

Fang Wang, Eun‐Kyoung Othelia Lee, Taixiang Wu, Herbert Benson, Gregory L. Fricchione, Weidong Wang, et al.

This review collected studies of tai chi up to May 31, 2013 and found that many trials reported benefits for mood and psychological well-being. The authors included 37 randomized controlled trials and 5 quasi-experimental studies from English and Chinese databases. A small pooled analysis of three randomized trials that measured…

Art Therapy and Mental Health Balance, Gait, and Falls Prevention Physical Activity and Health

Youth Screen Media Habits and Sleep

Lauren Hale, Gregory W. Kirschen, Monique K. LeBourgeois, Michael Gradisar, Michelle M. Garrison, Hawley E. Montgomery‐Downs, et al.

Many children and teens do not get enough sleep. Studies link use of screens, especially in the bedroom or in the hour before bed, to later bedtimes and less total sleep. Experts have set sleep-hour ranges for each age. Research also links short or disrupted sleep to emotional, behavioral, and…

Child Development and Digital Technology Sleep and related disorders Sleep and Wakefulness Research

Causes of Persistent Dizziness

Kurt Kroenke, Christine Lucas, Michael L. Rosenberg, Barbara Scherokman, Jerome E. Herbers, Paul A. Wehrle, et al.
Annals of Internal Medicine Summary & key facts 1992 262 citations

Researchers followed 100 outpatients (mean age 62) who kept having dizziness. They found that problems of the vestibular system (inner ear and balance) and psychiatric disorders were the most common causes. About half the patients had more than one factor making dizziness worse, and life‑threatening causes were rare.

Neuroscience of respiration and sleep Obstructive Sleep Apnea Research Vestibular and auditory disorders

Fatigue and Human Performance: An Updated Framework

Martin Behrens, Martin Gube, Hélmi Chaabène, Olaf Prieske, Alexandre Zénon, Kim‐Charline Broscheid, et al.
Sports Medicine Summary & key facts 2022 249 citations

This narrative review updates an earlier fatigue framework and proposes a clearer way to think about fatigue during tasks. It defines motor or cognitive task-induced state fatigue as a psychophysiological condition that can show up as a drop in performance and/or a stronger feeling of tiredness. The authors add cognitive…

Heart Rate Variability and Autonomic Control Occupational Health and Performance Sleep and Work-Related Fatigue

The effects of physical activity on cortisol and sleep: A systematic review and meta-analysis

Len De Nys, Kerry Anderson, Esther Frema Ofosu, Gemma C. Ryde, Jenni Connelly, Anna C. Whittaker
Psychoneuroendocrinology Summary & key facts 2022 227 citations

This review combined results from 10 intervention studies to see if physical activity programs change cortisol (a stress hormone) and sleep in adults. The pooled results found lower cortisol after activity programs and some improvement in sleep quality. The authors say the evidence is moderate for cortisol and low for…

Circadian rhythm and melatonin Physical Activity and Health Sleep and related disorders

Brief structured respiration practices enhance mood and reduce physiological arousal

Melis Yilmaz Balban, Eric Neri, Manuela M. Kogon, Lara Weed, Bita Nouriani, Booil Jo, et al.
Summary & key facts 226 citations

In a remote, randomized trial (NCT05304000), people did one of three five-minute daily breathing exercises or five minutes of mindfulness meditation each day for one month. The researchers measured mood, anxiety, and physiological arousal (breathing rate, heart rate, and heart rate variability). Breathwork—especially exhale-focused cyclic sighing—produced bigger mood gains and…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Mindfulness and Compassion Interventions

The Health-Related Quality of Life for Patients with Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS)

Michael Falk Hvidberg, Louise Brinth, Anne Vingaard Olesen, Karin Dam Petersen, Lars Holger Ehlers
PLoS ONE Summary & key facts 2015 212 citations

This study measured health-related quality of life (HRQoL) in Danish patients with ME/CFS using the EQ-5D-3L tool and found their scores were much lower than the general population and lower than 20 other conditions. The average (unadjusted) EQ-5D-3L score for the ME/CFS group was 0.47, while the population average was…

Fibromyalgia and Chronic Fatigue Syndrome Research Resilience and Mental Health
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