Frontier mental health research: psychedelics & drug studies

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48 papers

Cultures and Selves

Hazel Rose Markus, Shinobu Kitayama

This article reviews theory and research on how people and cultures shape each other. It defines the self as the “me” at the center of experience — a developing sense of awareness and agency that forms as a person (both brain and body) becomes tuned to different environments. The authors…

Cultural Differences and Values Social and Intergroup Psychology Social Representations and Identity

Effects of physical exercise on anxiety, depression, and sensitivity to stress

Peter Salmon
Clinical Psychology Review Summary & key facts 2001 1,332 citations

This 2001 review looked at studies on exercise, anxiety, depression, and stress. It found that short-term emotional effects of exercise are mixed, but many cross-sectional and longitudinal studies report that regular aerobic exercise training reduces anxiety and depression symptoms and may protect against the harmful effects of stress. The clearest…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Eating Disorders and Behaviors Mental Health Research Topics

Longitudinal evidence that fatherhood decreases testosterone in human males

Lee T. Gettler, Thomas W. McDade, Alan B. Feranil, Christopher W. Kuzawa

Postpartum depression can affect fathers too. Research summarized in this article says about 10% of men experience clinical paternal postpartum depression, often during pregnancy or in the first year after birth (with the highest risk in the first 3–6 months). The article lists common symptoms, risk factors like a partner’s…

Evolutionary Psychology and Human Behavior Neuroendocrine regulation and behavior Reproductive Health and Technologies

Survey study of challenging experiences after ingesting psilocybin mushrooms: Acute and enduring positive and negative consequences

Theresa M. Carbonaro, Matthew P. Bradstreet, Frederick S. Barrett, Katherine A. MacLean, Robert L. Jesse, Matthew W. Johnson, et al.
Journal of Psychopharmacology Summary & key facts 2016 526 citations

Psychedelic "bad trips" can be intense and sometimes last past the session. Surveys and studies report that a minority of users have serious short- or long-term problems, while other people later say the experience was meaningful or helpful. Risk and duration vary by dose, setting, and support, and studies give…

Body Image and Dysmorphia Studies Complementary and Alternative Medicine Studies Psychedelics and Drug Studies

The Neurodiversity Approach(es): What Are They and What Do They Mean for Researchers?

Patrick Dwyer
Human Development Summary & key facts 2022 417 citations

This paper says many people with ADHD have big problems with emotions. These problems include over-reacting, deep shame or guilt, and a strong sensitivity to rejection called rejection sensitive dysphoria (RSD). The author explains that emotions were often left out of ADHD research and diagnosis because they are not always…

Assistive Technology in Communication and Mobility Autism Spectrum Disorder Research Neuroethics, Human Enhancement, Biomedical Innovations

Midlife as a pivotal period in the life course

Margie E. Lachman, Salom M. Teshale, Stefan Agrigoroaei

Using long-term data from the Midlife in the United States (MIDUS) study, the authors show that physical health, thinking skills, and well-being in midlife can change in different directions for different people. They describe these changes as multidirectional (some things get better, some worse), variable between people, and plastic (open…

Aging and Gerontology Research Health disparities and outcomes Psychological Well-being and Life Satisfaction

Psychedelics reopen the social reward learning critical period

Romain Nardou, Edward J. Sawyer, Young Jun Song, M. F. Wilkinson, Yasmin Padovan‐Hernandez, Júnia L. de Deus, et al.
Nature Summary & key facts 2023 303 citations

Researchers gave different psychedelic drugs to mice and found the drugs could reopen a window of brain plasticity used for learning social rewards. This reopened window went along with changes in a social hormone system in a key reward area of the brain and with changes in genes that control…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies Psilocybin

The prevalence and burden of subthreshold generalized anxiety disorder: a systematic review

Heidemarie Haller, Holger Cramer, Romy Lauche, Florian Gaß, Gustav Dobos
BMC Psychiatry Summary & key facts 2014 270 citations

The article describes “high functioning anxiety” as a way some people with anxiety symptoms talk about their experience, not as an official medical diagnosis. It says people can look successful and cope outwardly while having common anxiety symptoms, and that diagnosis can be hard because the symptom effects may be…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Maternal Mental Health During Pregnancy and Postpartum

Default Mode Network Modulation by Psychedelics: A Systematic Review

James J Gattuso, Daniel Perkins, Simon Ruffell, Andrew J. Lawrence, Daniël Hoyer, Laura H. Jacobson, et al.

This systematic review looked at how classic psychedelics (LSD, psilocybin, ayahuasca) change activity in the brain’s Default Mode Network (DMN). The studies commonly found an acute disruption of connectivity inside the DMN and more communication between other resting‑state brain networks during the drug experience. The authors note these DMN changes…

Chemical synthesis and alkaloids Nicotinic Acetylcholine Receptors Study Psychedelics and Drug Studies

Life-Span Exposure to Low Doses of Aspartame Beginning during Prenatal Life Increases Cancer Effects in Rats

Morando Soffritti, Fiorella Belpoggi, Eva Tibaldi, Davide Degli Esposti, Michelina Lauriola

This is the Modern Slavery Statement for The Scott Trust, The Scott Trust Endowment Limited (STEL) and Guardian Media Group (GMG) for the year ending 31 March 2025. It explains the group structure, the main supply-chain areas, the policies and checks they use to reduce modern slavery risks, and actions…

Birth, Development, and Health Fatty Acid Research and Health Nutritional Studies and Diet

More treatment but no less depression: The treatment-prevalence paradox

Johan Ormel, Steven D. Hollon, Ronald C. Kessler, Pim Cuijpers, Scott M. Monroe
PubMed Summary & key facts 2022 188 citations

Treatments for depression have gotten better and far more people can get them since the 1980s. Yet the share of people in the general population with depression has not gone down. The authors call this the “treatment-prevalence paradox” and review seven possible explanations. They find little evidence that more cases…

Mental Health Research Topics Mental Health Treatment and Access Treatment of Major Depression

Ketamine for Depression, 4: In What Dose, at What Rate, by What Route, for How Long, and at What Frequency?

Chittaranjan Andrade

Researchers reviewed many studies on ketamine for depression and found that we still do not have firm answers about the best dose, how fast to give it, which way to give it, how long to treat, or how often to give treatments. Most studies used 0.5 mg/kg given over about…

Anesthesia and Sedative Agents Electroconvulsive Therapy Studies Treatment of Major Depression
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