Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

4 papers

Emotion-regulation strategies across psychopathology: A meta-analytic review

Amelia Aldao, Susan Nolen–Hoeksema, Susanne Schweizer
PubMed Summary & key facts 2010 6,290 citations

This meta-analysis combined 241 effect sizes from 114 studies to test how six habitual emotion-regulation strategies relate to symptoms of anxiety, depression, eating disorders, and substance-related problems. Rumination showed the strongest (large) link with symptoms. Avoidance, problem solving, and suppression showed medium-to-large links, while reappraisal and acceptance showed smaller (small-to-medium)…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Mental Health Research Topics

More treatment but no less depression: The treatment-prevalence paradox

Johan Ormel, Steven D. Hollon, Ronald C. Kessler, Pim Cuijpers, Scott M. Monroe
PubMed Summary & key facts 2022 188 citations

Treatments for depression have gotten better and far more people can get them since the 1980s. Yet the share of people in the general population with depression has not gone down. The authors call this the “treatment-prevalence paradox” and review seven possible explanations. They find little evidence that more cases…

Mental Health Research Topics Mental Health Treatment and Access Treatment of Major Depression

Clinical and subthreshold panic disorder

Alexander Bystritsky, Lauren Kerwin, Noosha Niv, Jaime L. Natoli, Natalie Abrahami, Ruth Klap, et al.
Depression and Anxiety Summary & key facts 2009 60 citations

This study reports that both full panic disorder (PD) and milder, “subthreshold” panic are linked with other mental health problems, trouble at work, and high use of health services. The authors used data from a large U.S. household survey to compare people with PD and varying levels of panic symptoms.…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Mental Health Research Topics Mental Health Treatment and Access

Is there a risk of addiction to ketamine during the treatment of depression? A systematic review of available literature

Gianmarco Ingrosso, Anthony J. Cleare, Mário F. Juruena
PubMed Summary & key facts 2025 13 citations

This systematic review looked at 16 studies of ketamine used to treat adults with depression, covering 2,174 patients. The authors found few clear cases of tolerance or dependence (four patients) and conclude that, overall, ketamine appears relatively safe for depression when given under medical supervision, with careful monitoring and dosing.…

Mental Health Research Topics Treatment of Major Depression Tryptophan and brain disorders Ketamine
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