Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.
16 papers
This review says our sense of being a body comes from the brain combining many body signals. It describes three parts of bodily self-consciousness: self-identification (feeling a body is mine), self-location (where I feel I am), and the first-person perspective (the point from which I see). Experiments that create mismatched…
Attachment theory, described about 40 years ago, explains stable ways people form close bonds. This review sums up brain imaging and cognitive studies that link adult attachment styles (secure, avoidant, anxious, resolved/unresolved) to how people feel about and think about others. It proposes that attachment style shapes quick judgments of…
This review looks at studies in humans and animals that link anxiety and stress with poorer cognitive flexibility — the ability to change strategies when rules or goals change. It describes evidence that the prefrontal cortex (PFC) is central to flexible behavior, that anxiety or PFC disruptions are associated with…
A single dose of psilocybin, a psychedelic that acutely causes distortions of space-time perception and ego dissolution, produces rapid and persistent therapeutic effects in human clinical trials1-4. In animal models, psilocybin induces neuroplasticity in cortex and hippocampus5-8. It remains unclear how human brain network changes relate to subjective and lasting…
Research links ADHD — which shows up as inattention, impulsivity, and too much activity — to weaker structure and function in the brain’s prefrontal cortex (PFC), especially on the right side. The PFC helps control top-down attention, stop inappropriate actions, and regulate emotion, and it needs the right balance of…
Several brain-imaging studies found that people with long-term work-related burnout showed differences in brain structure and function compared with matched healthy adults. In groups where participants had worked more than about 60–70 hours per week for several years, researchers reported larger amygdala size, thinner medial prefrontal cortex (mPFC) tissue, weaker…
In a small randomized, double-blind crossover study of 15 men with chronic radicular lower‑limb neuropathic pain, a single sublingual dose of THC (about 15.4 mg on average) reduced pain more than placebo. The amount of pain relief was linked to changes on resting‑state fMRI: reduced connectivity between emotional/cognitive brain areas…
Researchers studied 32-day-old juvenile rats that were allowed 30 minutes of rough-and-tumble play. Right after play, the rats showed higher levels of BDNF messenger RNA in the amygdala and dorsolateral frontal cortex, measured with in situ hybridization. The authors suggested this could mean play helps shape brain areas tied to…
This review paper brings together animal and human studies to explain how alcohol and stress hormones may change the prefrontal cortex and the body’s stress system as drinking moves from casual use toward dependence. The authors say alcohol raises stress hormones (glucocorticoids) right away, and repeated heavy use can produce…
The paper reports that severe iron deficiency anemia in infancy is linked with poor health and lasting brain and behavior problems. It says lack of iron can change the hippocampus and corpus striatum and alter brain chemicals (serotonin, noradrenaline, dopamine). These brain changes are tied to behaviors in babies (wariness,…
Scientists reviewing lab rat studies say juvenile 'play fighting' helps shape the social brain. Research over the past 100+ years shows that when young rats are deprived of normal peer play during the juvenile period, adult rats show socio-cognitive problems and changes in neurons in the prefrontal cortex, especially the…
This randomized, double-blind, placebo-controlled crossover study gave subanesthetic S‑ketamine to 24 healthy young people while recording fMRI and EEG at rest. After ketamine, fMRI showed less connectivity in the medial prefrontal cortex and more connectivity in left and right intraparietal (parietal) areas of the default mode network. EEG showed more…
