The Functional Role of Large-scale Brain Network Coordination in Placebo-induced Anxiolysis
This fMRI study tested how expecting an anxiety-reducing treatment (a placebo) changed large-scale brain networks. Under placebo, the brain's salience network became less active, especially to threat cues. The rostral anterior cingulate cortex (rACC) showed stronger ongoing connections with the salience network, and this stronger connectivity was linked with lower…