Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

2 papers

Cannabis analgesia in chronic neuropathic pain is associated with altered brain connectivity

Libat Weizman, Lior Dayan, Silviu Brill, Hadas Nahman‐Averbuch, Talma Hendler, Giris Jacob, et al.
Neurology Summary & key facts 2018 117 citations

In a small randomized, double-blind crossover study of 15 men with chronic radicular lower‑limb neuropathic pain, a single sublingual dose of THC (about 15.4 mg on average) reduced pain more than placebo. The amount of pain relief was linked to changes on resting‑state fMRI: reduced connectivity between emotional/cognitive brain areas…

Cannabis and Cannabinoid Research Pain Mechanisms and Treatments Psychedelics and Drug Studies Cannabis

The brain-body disconnect: A somatic sensory basis for trauma-related disorders

Breanne E Kearney, Ruth A Lanius
PubMed Central (PMC) Summary & key facts 2022 116 citations

This review paper suggests that problems in body-based senses — especially the vestibular system (balance/motion) and the somatosensory system (touch and body position) — may help explain many symptoms of trauma-related disorders. The authors propose that trauma can disrupt low-level, brainstem sensory processing and that this disruption can cascade into…

Action Observation and Synchronization Mental Health and Psychiatry Psychosomatic Disorders and Their Treatments
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