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6 papers
Researchers found that the main kratom alkaloid, mitragynine, is turned by liver enzymes into a much more active compound called 7-hydroxymitragynine (7‑OH). In lab tests and in mice, 7‑OH acts more strongly at the mu-opioid receptor and reaches brain levels that can explain most or all of the pain relief…
Researchers isolated a new natural cannabis compound called Δ9-tetrahydrocannabiphorol (Δ9-THCP) and its CBD counterpart (CBDP). In lab tests, Δ9-THCP bound very strongly to the human CB1 receptor (Ki = 1.2 nM) and caused THC-like effects in mice (less movement, pain relief, catalepsy, and lower body temperature). The authors say Δ9-THCP…
This page describes ibogaine as a plant-derived psychedelic that some researchers are studying for addiction, depression, and PTSD. It says ibogaine can cause strong hallucinations that start within hours and may last up to 24 hours. The page reports some studies and a 2022 review that suggest ibogaine may reduce…
This lab study tested how the cannabis compound THCA-A binds to the two main cannabinoid receptors (CB1 and CB2). The THCA-A sample was found to contain 2% THC, and THCA-A showed only very weak binding and little or no effect at these receptors. The authors say some of the small…
This study gave the same oral dose of cannabidiol (CBD) to male and female rats using three product types: isolate, broad‑spectrum, and full‑spectrum. When CBD was given as a full‑spectrum product that included about 0.2% THC, CBD blood levels were higher than with isolate or broad‑spectrum. Lab tests showed THC…
Researchers reviewing ibogaine and its chemical relatives say these drugs point to a new way to treat substance use disorders by blocking a brain receptor called α3β4 nicotinic acetylcholine receptor (nAChR). Animal studies found ibogaine and some derivatives reduced self-use of drugs like morphine, cocaine, alcohol, and nicotine. But ibogaine…
