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2 papers
In rats and mice that had brain lesions used to model Parkinson's disease, the plant compound Δ9-THCV reduced movement problems after a single dose and, with repeated dosing, reduced loss of dopamine-producing neurons in the brain region called the substantia nigra. Some effects seem linked to antioxidant actions and, in…
In this rat study, animals got a single injection of ibogaine at 20 mg/kg or 40 mg/kg and the researchers measured three neurotrophic factors (GDNF, BDNF, NGF) in four brain regions (VTA, prefrontal cortex, nucleus accumbens, substantia nigra) at 3 and 24 hours. The main changes appeared at 24 hours:…
