Frontier mental health research: psychedelics & drug studies

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4 papers

Longitudinal evidence that fatherhood decreases testosterone in human males

Lee T. Gettler, Thomas W. McDade, Alan B. Feranil, Christopher W. Kuzawa

Postpartum depression can affect fathers too. Research summarized in this article says about 10% of men experience clinical paternal postpartum depression, often during pregnancy or in the first year after birth (with the highest risk in the first 3–6 months). The article lists common symptoms, risk factors like a partner’s…

Evolutionary Psychology and Human Behavior Neuroendocrine regulation and behavior Reproductive Health and Technologies

Sex differences in anxiety and depression: Role of testosterone

Jenna A. McHenry, Nicole Carrier, Elaine M. Hull, Mohamed Kabbaj
Frontiers in Neuroendocrinology Summary & key facts 2013 487 citations

This review examines studies on how testosterone relates to anxiety and depression and how that might help explain sex differences in these disorders. About 18% of U.S. adults have an anxiety disorder each year and about 7% have major depressive disorder, and women are more than twice as likely as…

Hormonal and reproductive studies Neuroendocrine regulation and behavior Stress Responses and Cortisol

Rethinking Menopausal Hormone Therapy: For Whom, What, When, and How Long?

Leslie Cho, Andrew M. Kaunitz, Stephanie S. Faubion, Sharonne N. Hayes, Emily S. Lau, Nicole Pristera, et al.
Circulation Summary & key facts 2023 157 citations

Past large trials found that using combined estrogen and progestin was linked to higher heart-related risk, and hormone therapy (HT) use fell a lot afterward. In the last 20 years, research shows that when HT starts (age and time since menopause) and how it is given (route) affect heart disease…

Estrogen and related hormone effects Menopause: Health Impacts and Treatments Phytoestrogen effects and research

Testosterone in Female Depression: A Meta-Analysis and Mendelian Randomization Study

Dhruba Tara Maharjan, Ali Alamdar Shah Syed, Guan Ning Lin, Weihai Ying
Biomolecules Summary & key facts 2021 28 citations

This paper combined past studies (a meta-analysis) and a genetic test (Mendelian randomization) to look at blood testosterone and depression in women. The meta-analysis found that women with depression have significantly different serum testosterone levels than healthy women, with a clear result in premenopausal women and weaker (borderline) results in…

Hormonal and reproductive studies Hypothalamic control of reproductive hormones Stress Responses and Cortisol
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