Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

25 papers

Mindfulness-Based Stress Reduction for Stress Management in Healthy People: A Review and Meta-Analysis

Alberto Chiesa, Alessandro Serretti

MBSR is able to reduce stress levels in healthy people. However, important limitations of the included studies as well as the paucity of evidence about possible specific effects of MBSR in comparison to other nonspecific treatments underline the necessity of further research.

COVID-19 and Mental Health Mindfulness and Compassion Interventions Resilience and Mental Health

Self-Compassion: Theory, Method, Research, and Intervention

Kristin D. Neff
PubMed Summary & key facts 2023 721 citations

This review defines self-compassion as being supportive toward yourself during suffering and presents a six-part model (more self-kindness and common humanity and mindfulness; less self-judgment, isolation, and overidentification). It summarizes a growing set of empirical studies that suggest self-compassion helps people handle distressing thoughts and emotions and is linked to…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Mindfulness and Compassion Interventions

Mindfulness-Based Interventions for Anxiety and Depression

Stefan G Hofmann, Angelina F Gómez
PubMed Central (PMC) Summary & key facts 2017 706 citations

Mindfulness-based interventions (MBIs), especially Mindfulness-Based Stress Reduction (MBSR) and Mindfulness-Based Cognitive Therapy (MBCT), teach people to pay nonjudgmental attention to the present moment. Reviews and randomized trials show MBIs can reduce anxiety and depression symptom severity across many groups, often doing better than non-evidence treatments or active controls and performing…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Mindfulness and Compassion Interventions

Narcissistic Personality Disorder: Diagnostic and Clinical Challenges

Eve Caligor, Kenneth N. Levy, Frank E. Yeomans
American Journal of Psychiatry Summary & key facts 2015 244 citations

Borderline personality disorder (BPD) and narcissistic personality disorder (NPD) are different but can look similar. BPD is marked by unstable moods, a shifting sense of self, fear of abandonment, and often impulsive or self-harming behavior. NPD is marked by grandiosity, a strong need for admiration, low empathy, and using others…

Personality Disorders and Psychopathology Personality Traits and Psychology Transactional Analysis in Psychotherapy

Brief structured respiration practices enhance mood and reduce physiological arousal

Melis Yilmaz Balban, Eric Neri, Manuela M. Kogon, Lara Weed, Bita Nouriani, Booil Jo, et al.
Summary & key facts 226 citations

In a remote, randomized trial (NCT05304000), people did one of three five-minute daily breathing exercises or five minutes of mindfulness meditation each day for one month. The researchers measured mood, anxiety, and physiological arousal (breathing rate, heart rate, and heart rate variability). Breathwork—especially exhale-focused cyclic sighing—produced bigger mood gains and…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes COVID-19 and Mental Health Mindfulness and Compassion Interventions

Meditation and yoga for posttraumatic stress disorder: A meta-analytic review of randomized controlled trials

Autumn M. Gallegos, Hugh F. Crean, Wilfred R. Pigeon, Kathi L. Heffner
Clinical Psychology Review Summary & key facts 2017 178 citations

This paper pooled results from 19 randomized trials with 1,173 adults to see if meditation and yoga change PTSD symptoms. Overall, these mind–body practices were linked to a small-to-medium reduction in PTSD symptoms (effect size = −0.39). The authors found no big differences by type of practice, who was studied,…

Mindfulness and Compassion Interventions Posttraumatic Stress Disorder Research Resilience and Mental Health

Breathing‐Based Meditation Decreases Posttraumatic Stress Disorder Symptoms in U.S. Military Veterans: A Randomized Controlled Longitudinal Study

Emma Seppälä, Jack B. Nitschke, Dana Tudorascu, Andrea S Hayes, Michael R. Goldstein, Dong T. H. Nguyen, et al.
Journal of Traumatic Stress Summary & key facts 2014 177 citations

This randomized study tested a breathing-based meditation (Sudarshan Kriya yoga) in 21 male U.S. veterans of the Iraq or Afghanistan wars. Participants were randomly assigned to the meditation group (n = 11) or a waitlist control (n = 10). The meditation group showed reductions in self-reported PTSD symptoms, anxiety, and…

Mindfulness and Compassion Interventions Posttraumatic Stress Disorder Research Stress Responses and Cortisol

Psychedelic Harm Reduction and Integration: A Transtheoretical Model for Clinical Practice

Ingmar Gorman, Elizabeth M Nielson, Aja Molinar, Ksenia Cassidy, Jonathan Sabbagh
PubMed Central (PMC) Summary & key facts 2021 124 citations

Psychedelic Harm Reduction and Integration (PHRI) is a clinical model for working with people who use or are thinking about using psychedelics. It blends harm-reduction therapy with methods from psychedelic-assisted therapy, can be used in short or ongoing psychotherapy, and aims to be compassionate and non-stigmatizing rather than focused only…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies

Stress: Neurobiology, consequences and management

Anil Kumar, Puneet Rinwa, Gurleen Kaur, Lalit Machawal

This 2013 review explains how physical and psychological stress change the brain and body. It describes how stress activates the HPA (hypothalamic–pituitary–adrenal) system and alters brain chemicals such as GABA, dopamine, norepinephrine and serotonin. The paper also covers short-term memory effects, animal models used to study chronic stress, and both…

Medicinal Plants and Neuroprotection Mindfulness and Compassion Interventions Stress Responses and Cortisol

Effects of Singing Bowl Sound Meditation on Mood, Tension, and Well-being: An Observational Study

Tamara L. Goldsby, Michael E. Goldsby, Mary McWalters, Paul J. Mills

This observational study tested Tibetan singing bowl sound meditation with 62 adults (mean age 49.7). After the session, people reported less tension, anger, fatigue, and depressed mood, and higher spiritual well-being. People who had never tried this meditation before showed a larger drop in tension than people who had experience.…

Music Therapy and Health Neuroscience and Music Perception Sleep and related disorders

On the need for metaphysics in psychedelic therapy and research

Sjöstedt-Hughes, Peter
www.frontiersin.org Summary & key facts 2023 46 citations

This paper argues that psychedelic-assisted therapy should include optional, clear discussion of metaphysical views during integration. It presents a "Metaphysics Matrix" schema and a new "Metaphysics Matrix Questionnaire (MMQ)" as tools to help integrate and to measure metaphysical aspects of psychedelic experiences. The authors say metaphysics (a branch of philosophy…

Chemical synthesis and alkaloids Complementary and Alternative Medicine Studies Psychedelics and Drug Studies

Differential Experimental Effects of a Short Bout of Walking, Meditation, or Combination of Walking and Meditation on State Anxiety Among Young Adults

Meghan K. Edwards, Simon Rosenbaum, Paul D. Loprinzi

This randomized trial tested whether a single short bout of walking, meditation, or a combination changed short-term anxiety in young adults. One hundred ten university students (mean age 21.4 years) were randomly assigned to 10 minutes of walking, 10 minutes of meditation, walking then meditation, meditation then walking, or sitting.…

Mindfulness and Compassion Interventions Sleep and related disorders Urban Green Space and Health
Summaries and links are for general information and education only. They are not a substitute for reading the original publication or for professional medical, legal, or other advice. Always refer to the linked source for the full study.